Search Results - M. S. Zainulina

Aim: to justify a differentiated approach to the treatment of obstetric coagulopathic bleeding depending on the nature of hemostasis disorders.Materials and Methods. A prospective cohort study was conducted involving 52 patients with postpartum hemorrhage (PPH) who gave a child birth between 2021 an...

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An obstetrician-gynecologist faces in clinical practice cases requiring to weigh up not only benefits of administering preventive agents for venous thromboembolic complications (VTEC) but also risks related to concomitant coagulopathy. Here, we discuss issues related to using low molecular weight he...

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Introduction. At present, hemostasis disorders still hold one of the lead places in the pathogenesis of reproductive losses associated with high risk of miscarriage and remain one of the major causes for developing serious obstetric complications. Relevance, efficacy and safety of using drugs contai...

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The article is timed to the 245th anniversary of V.F. Snegirev Maternity Hospital № 6 (St. Petersburg). We take an insight into a remarkable story of this Institution from its foundation to the present. Through its history, this maternity hospital was led by outstanding obstetricians who contributed...

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Introduction. The role of antiphospholipid antibody (APA) carriage in the pathogenesis of pregnancy failure is one of the most recently debated issues. To date, no unified therapeutic approach to immunotherapy of antiphospholipid syndrome (APS) in pregnancy exists. Intravenous immunoglobulins (IVIG)...

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Here, we discuss blood management upon a risk of massive obstetric hemorrhage by describing a clinical case of female patient with obstetric complications of pregnancy such as severe preeclampsia and chronic placental insufficiency with fetal malnutrition examined by using thromboelastometry to asse...

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Introduction. Antiphospholipid syndrome (AРS) is a multisystem disease characterized by elevated levels of antiphospholipid antibodies (AРA), arterial and/or venous thrombosis, thrombocytopenia, and habitual miscarriage. Various AРA types have multifactorial and indirect effects on pregnancy course...

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Introduction. Antiphospholipid antibodies (APAs) exert multifaceted effects on the course of pregnancy by disrupting microcirculation, affecting the hemostasis, as well as damaging the endothelial membranes, leading to early reproductive loss and development of placenta-associated complications depe...

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Antiphospholipid antibodies by disrupting trophoblast invasion and endometrial angiogenesis might contribute to a defective placentation and, in turn, affect the successful beginning of pregnancy. It is well known and proven that these processes begin with the founding of the utero-placental blood f...

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Our objective was to demonstrate the efficiency of therapy for antiphospholipid syndrome (APS) in pregnant women using plasmapheresis and intravenous immunoglobulins.92 women with diagnosed APS and 47 APS-free women with physiological pregnancy were under study. APS was diagnosed in accordance with...

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Bleeding during pregnancy, labor and delivery is considered the major cause of maternal death or subsequent disability, and various disorders. Currently, obstetricians and gynecologists have a number of effective tools for the prevention and treatment of obstetrical bleedings. Compliance with the Fe...

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Introduction. Women with infertility and circulating antiphospholipid  antibodies  (APA) may be at risk of reproductive losses. A possible way to improve their in vitro fertilization  (IVF) outcomes is the immunomodulating  therapy using intravenous immunoglobulin (IVIG). Aim: to study the effecacy...

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An issue of venous thromboembolic events (VTEs) in pregnant women and puerperas in Russia as well as throughout the world remains relevant. Specialized events with expert’s participation could not be better to promote active discussion and constructive solution of complex problems, which refer to is...

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The aim of the study was to determine the efficacy of heparin prophylaxis in preventing pregnancy complications in patients with the manifested laboratory phenotype – resistance to activated protein C (APC-resistance with NR ≤ 0.49) Factor V Leiden mutation (GA genotype). Materials and methods. A si...

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Activated platelets aggregate with monocytes by binding membrane bound molecules. Platelet-monocyte interaction is considered to underlie pathophysiological mechanisms bridging thrombosis and inflammation. Detection and analysis of platelet-monocyte complexes (PMC) provide means for revealing their...

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Aim: to evaluate efficacy of plasmapheresis combined with low molecular weight heparins (LMWH) and acetylsalicylic acid (ASA).Materials and Methods. 327 plasmapheresis sessions were performed for 75 patients: 17 (22.6 %) patients during preparation for pregnancy, 11 (19.0 %) pregnant women in the fi...

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Aim: to study the association between prothrombin activity in the blood plasma and gestational complications in women with the prothrombin G20210A mutation.Materials and methods. A prospective clinical cohort study including 290 pregnant women aged 18 to 45 years was conducted from 2012 to 2018. Two...

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Abstract.  Leukocyte  recruitment  to  placental  tissue  is  an  important  factor  of  its  development.  In  this respect, adhesion molecules at the endothelial cell surface represent a key determining factor of leukocyte adhesion and their trans-endothelial migration. The goal of investigation w...

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Abstract. In course of physiological pregnancy, peripheral blood CD4+T-lymphocytes normally migrate to the uterine decidual tissue. Hence, this study aimed to compare expression profiles of adhesion molecules and chemokine receptors on the surface of CD4+T-lymphocytes from peripheral blood in health...

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Aim. To create a collection of samples from women at different stages of pregnancy to search for early biomarkers of preterm birth.Material and methods. In order to standardize the sample collection, standard operation procedures have been developed with a step-by-step protocol for each research mem...

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