Search Results - M. S. Pokrovskaya

The authors state that in a certain sense the learning problems of different groups of students (healthy and auditory impaired) are similar and can be solved by common pedagogical methods. The article presents the ways of integration of pedagogical technologies developedfor healthy and hearing-impai...

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Risk management is a key aspect of the organization and management of biobanks, which is part of the overall quality management system aimed at early detection, analysis and minimization of events, that can lead to negative consequences for the biobank, as well as affect the quality of biosamples an...

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Aim. To create the concept of the national information platform of biobanks of the Russian Federation (NIPB RF).Material and methods. In April 2022, an expert group consisting of 17 representatives of Russian biobanks was formed in National Association of Biobanks and Biobanking Specialists to creat...

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To implement a modern personalized approach in practical healthcare, the latest biomedical technologies should be developed and genetic research should be performed. The analysis of a substantial quantity of data is essential for the investigation of the prevalence of genetic risk factors for variou...

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Aim. To create and validate an algorithm for automatic aliquoting of serum and plasma samples for biobanking as part of a large-scale study.Material and methods. Biobank of the National Medical Research Center for Therapy and Preventive Medicine is equipped with a Tecan automated aliquoting system....

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The search for early disease markers and the development of diagnostic systems has recently been expanding within genomics. Genomic deoxyribonucleic acid (DNA), cell-free DNA (cfDNA) and microbiome DNA obtained from different types of samples (tissues, blood and its derivatives, feces, etc.) are use...

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Aim. To develop an algorithm and manage total biobanking of samples of whole blood, serum and plasma of patients in the hospital of the National Medical Research Center for Therapy and Preventive Medicine in order to create a detailed biosample collection through the integration of electronic medica...

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Aim. To analyze the interactions between heat shock proteins (HSPs) (HSP27, HSP70 and cardiovascular HSP — cvHSP) serum levels and acute decompensated heart failure (HF) and signs of venous congestion in patients with preserved ejection fraction (HFpEF).Material and methods. The study included 80 pa...

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Information on morbidity is presented in statistical reports for the entire population of multinational subjects of Russia, but population Biobanks contain information on individual peoples.Aim. To develop a technology for assessing the frequency of deoxyribonucleic acid (DNA) markers for administra...

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Aim. Maturity- onset diabetes of the young (MODY) is a group of monogenic diseases with an autosomal dominant inheritance. This is a rarely diagnosed disease, occurring in 1 of 10 thousand adults and in 1 of 23 thousand children. Brief description. We present a case report of a patient with a monoge...

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The advances of biomedicine include the new technologies, diagnosis and treatment techniques, as well as the practical use of new types of biological targets, in particular, nucleic acids. Genomic deoxyribonucleic acid (DNA), extracellular DNA (exDNA) and microbiome DNA obtained from different types...

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Biosample preservation for future research is a fundamental component of translational medicine. At the same time, the value of stored biosamples is largely determined by the presence of related clinical data and other information. Electronic medical records are a unique source of a large amount of...

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Aim. To study the relationship of gut microbiota (GM) with serum myocardial fibrosis markers in patients with heart failure with preserved ejection fraction (HFpEF).Material and methods. The composition of the gut microbiota among 42 patients with HFpEF aged 67,0 [64,0; 71,5] years (men, 57,1%) was...

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Until now, there remains a certain interest in studying the role of booster vaccination  in  the  formation  of  post-vaccination  immunity  against  the Severe  acute  respiratory  syndrome  coronavirus  2  (SARS-CoV-2).  The variety  of  vaccine  platforms  provides  the  opportunity  to  choose ...

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Aim. To study the effect of standard serum long-term storage at -70О C and with a single thawing on the biochemical markers by comparing the results of studies carried out in 2013-2014 and 2020.Material and methods. The material was the blood serum of participants in the ESSE-RF study, which was sto...

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Along with efficacy and safety, it is extremely important to study the severity of humoral and cellular immunity during not only vaccination, but also revaccination against the Severe Acute Respiratory Syndromerelated CoronaVirus 2 (SARS-CoV-2).Aim. To compare the immunogenicity (humoral and cellula...

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Aim. To analyze the relationship between the concentrations of circulating heat shock proteins (HSP): HSP27, HSP70 and cardiovascular HSP (cvHSP) with the course of heart failure with preserved ejection fraction (HFpEF) and the outcomes of acute decompensated HFpEF (ADHFpEF).Material and methods. A...

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Aim. To assess the distribution of cardiac troponin I (cTnI) in a sample of the region from the ESSE-RF study and to study its associations with risk factors (RFs) and the Systematic Coronary Risk Evaluation (SCORE) system.Material and methods. This observational cross-sectional study includes a rep...

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Aim. As part of a pilot study, to investigate the potential significance of cardiac troponin I (cTnI) in assessing the risk of cardiovascular diseases (CVD) in general population aged 35-64 years of one of the regions from the ESSE-RF study.Material and methods. The study is based on the ESSE-RF obs...

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