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    Spatial transcriptomics reveals Inhba/Smad2/E2f4 axis in Lrp2high thecal cell proliferation in androgen-induced PCOS mice

    Spatial transcriptomics reveals Inhba/Smad2/E2f4 axis in Lrp2high thecal cell proliferation in androgen-induced PCOS mice 由 Man Luo, Man Luo, Xiaona Tian, Li Li, Guomei Zhang, Wenzhi Liu, Linlin Mei, Haoran Li, Xiaoyan You, Dongmei Zhang, Mengsi Zhou, Mengsi Zhou, Cheng Xiao, Cheng Xiao, Jianping Ye, Jianping Ye, Xiaofeng Yang, Xiaofeng Yang

    出版 2025-08-01

    BackgroundPolycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by elevated androgen levels and impaired follicular development. A hallmark of PCOS is the excessive proliferation of thecal cells (TCs), which are critical for androgen production. However, the molecular mechani...

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