Rezultaty - Ling Zhao

To solve the problems of insufficient global optimization ability and easy loss of population diversity in building interior layout design, this study proposes a novel layout optimization model integrating interactive genetic algorithm and improved differential evolutionary algorithm to improve the...

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<i>Calocybe indica</i> (milky mushroom), an edible mushroom with significant nutritional value, shows potential for cultivation in subtropical regions. Investigating the composition and diversity of the microbial community structure of the casing materials of <i>C. indica</i>...

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<b>Background:</b> Allergic rhinitis (AR) is a prevalent allergic disorder characterized by a complex pathogenesis. Drawing on traditional Chinese medicine theory and contemporary pharmacological principles, this study developed an inhalation-based herbal formulation, ZHW, to explore a n...

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ObjectiveAnxiety and depression are common mental disorders in the elderly. Concurrent frailty may lead to worse clinical outcomes. This study examined the network structures of anxiety and depression in frail and non-frail older adults.MethodsThe Center for Epidemiologic Studies Depression Scale-10...

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IntroductionCurcumin has been found to inhibit atherosclerosis. However, its poor stability and low activity severely limit its further application. To overcome the shortcomings of curcumin, our team successfully designed a novel curcumin analog, CACN136. This study aims to explore the anti-atherosc...

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The partial substitution of carbon black with steel slag powder (SSP) in the preparation of steel slag powder-carbon black/styrene-butadiene rubber composites (SSP–CB/SBR) is an effective approach to enhancing the high-value utilization of SSP. The compatibility of SSP–CB/SBR is fundamental to the d...

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Objective Prognostic nutritional index (PNI) is an index for assessing nutritional and immune status. The aim of this study is to investigate the predictive value of PNI for long-term major adverse cardiac and cerebrovascular events (MACCE) in ST-segment elevation myocardial infarction (STEMI) patie...

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Snow cover, as a critical component of the cryosphere, serves as a vital water resource for arid regions in Northwest China. The Qilian Mountains (QLM), situated on the northeastern margin of the Tibetan Plateau, function as an important ecological barrier and water conservation area in western Chin...

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Chronic migraine (CM) is a debilitating neurological disorder, yet the glial-specific mechanisms underlying its pathophysiology in the trigeminal nucleus caudalis (TNC)—a critical hub for craniofacial pain processing—remain poorly understood. Here, we employed single-nucleus RNA sequencing (snRNA-se...

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Background: Immune escape is a critical barrier to effective cancer immunotherapy for cancers such as hepatocellular carcinoma (HCC). The aim of this study was to identify prognostic genes associated with immune escape and to analyse immune infiltration in HCC. Methods: The TCGA-LIHC cohort gene exp...

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Haemophilus parasuis (H. parasuis) causes exudative inflammation, implying endothelial dysfunction during pathogen infection. However, so far, the molecular mechanism of endothelial dysfunction caused by H. parasuis has not been clarified. By using the transwell-based cell co-culture system, we demo...

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BackgroundMitral valve disease is associated with higher cardiovascular morbidity and mortality. Glycemic variability (GV), reflecting blood glucose fluctuations, acts as an independent indicator for results in critically ill patients. However, it’s effect on patients in the ICU with mitral valve di...

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In this study we report the results of a decade-long breeding program for japonica super rice made by Nanjing Branch of Chinese National Center for Rice Improvement in Jiangsu Academy of Agricultural Sciences. We concluded that selection of parents with good comprehensive traits and complementary ad...

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The persistence and clinical consequences of rabies virus (RABV) infection have prompted global efforts to develop a safe and effective vaccines against rabies. mRNA vaccines represent a promising option against emerging and re-emerging infectious diseases, gaining particular interest since the outb...

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Abstract Irinotecan (CPT11)‐induced diarrhea affects 80–90% of cancer patients due to β‐glucuronidase (GUS) converting 7‐ethyl‐10‐hydroxycamptothecin glucuronide (SN38G) to 7‐ethyl‐10‐hydroxycamptothecin (SN38). It remains unclear whether SN38 impacts the homeostasis between gut microbiota and mucos...

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Major depressive disorder (MDD) is a heterogeneous mental disorder involving multiple pathogenic mechanisms. Current first-line antidepressant medications suffer from slow onset of action, limited effectiveness, and high side effects, necessitating the search for new therapeutic targets. Targeting c...

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Soil salinity threatens crop yields, but the molecular basis of crop tolerance to salt stress remain not fully understood currently. This study establish OsWRKY72 enhances salt tolerance in rice via SKC1-mediated Na+ regulation. As a group IIc WRKY transcription factor, OsWRKY72 does not possess can...

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