Результаты поиска - Ling ZHAO
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Optimization design of internal space layout of three-bedroom residential apartment based on IGA and DE algorithm.
Опубликовано 2025-01-01Полный текстTo solve the problems of insufficient global optimization ability and easy loss of population diversity in building interior layout design, this study proposes a novel layout optimization model integrating interactive genetic algorithm and improved differential evolutionary algorithm to improve the...
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Microbiome Dynamics in Four Different Casing Materials Used for Milky Mushroom (<i>Calocybe indica</i>) Cultivation
Опубликовано 2025-06-01Полный текст<i>Calocybe indica</i> (milky mushroom), an edible mushroom with significant nutritional value, shows potential for cultivation in subtropical regions. Investigating the composition and diversity of the microbial community structure of the casing materials of <i>C. indica</i>...
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Therapeutic Effects and Mechanisms of the Inhaled Traditional Chinese Medicine Compound ZHW on Allergic Rhinitis
Опубликовано 2025-07-01Полный текст<b>Background:</b> Allergic rhinitis (AR) is a prevalent allergic disorder characterized by a complex pathogenesis. Drawing on traditional Chinese medicine theory and contemporary pharmacological principles, this study developed an inhalation-based herbal formulation, ZHW, to explore a n...
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The relationship between frailty in older adults and anxiety and depression in china: propensity score matching and network analysis
Опубликовано 2025-07-01Полный текстObjectiveAnxiety and depression are common mental disorders in the elderly. Concurrent frailty may lead to worse clinical outcomes. This study examined the network structures of anxiety and depression in frail and non-frail older adults.MethodsThe Center for Epidemiologic Studies Depression Scale-10...
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Anti atherosclerosis effect and mechanism of a novel curcumin analogue CACN136: regulating macrophage M1/M2 polarization and lipid metabolism
Опубликовано 2025-06-01Полный текстIntroductionCurcumin has been found to inhibit atherosclerosis. However, its poor stability and low activity severely limit its further application. To overcome the shortcomings of curcumin, our team successfully designed a novel curcumin analog, CACN136. This study aims to explore the anti-atherosc...
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Molecular dynamics simulation and flame-retardant characterization of steel slag powder-modified styrene-butadiene rubber composites
Опубликовано 2025-07-01Полный текстThe partial substitution of carbon black with steel slag powder (SSP) in the preparation of steel slag powder-carbon black/styrene-butadiene rubber composites (SSP–CB/SBR) is an effective approach to enhancing the high-value utilization of SSP. The compatibility of SSP–CB/SBR is fundamental to the d...
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Prognostic nutritional index in the prediction of adverse cardiac and cerebrovascular events in ST-segment elevation myocardial infarction patients with type 2 diabetes mellitus in...
Опубликовано 2025-06-01Полный текстObjective Prognostic nutritional index (PNI) is an index for assessing nutritional and immune status. The aim of this study is to investigate the predictive value of PNI for long-term major adverse cardiac and cerebrovascular events (MACCE) in ST-segment elevation myocardial infarction (STEMI) patie...
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Long-Term Snow Cover Change in the Qilian Mountains (1986–2024): A High-Resolution Landsat-Based Analysis
Опубликовано 2025-07-01Полный текстSnow cover, as a critical component of the cryosphere, serves as a vital water resource for arid regions in Northwest China. The Qilian Mountains (QLM), situated on the northeastern margin of the Tibetan Plateau, function as an important ecological barrier and water conservation area in western Chin...
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Single-Nucleus Transcriptomics Reveals Glial Metabolic–Immune Rewiring and Intercellular Signaling Disruption in Chronic Migraine
Опубликовано 2025-06-01Полный текстChronic migraine (CM) is a debilitating neurological disorder, yet the glial-specific mechanisms underlying its pathophysiology in the trigeminal nucleus caudalis (TNC)—a critical hub for craniofacial pain processing—remain poorly understood. Here, we employed single-nucleus RNA sequencing (snRNA-se...
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Identification of immune escape-related prognostic genes and immune infiltration analysis in hepatocellular carcinoma based on bioinformatics
Опубликовано 2025-09-01Полный текстBackground: Immune escape is a critical barrier to effective cancer immunotherapy for cancers such as hepatocellular carcinoma (HCC). The aim of this study was to identify prognostic genes associated with immune escape and to analyse immune infiltration in HCC. Methods: The TCGA-LIHC cohort gene exp...
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Resistin secreted by porcine alveolar macrophages leads to endothelial cell dysfunction during Haemophilus parasuis infection
Опубликовано 2023-12-01Полный текстHaemophilus parasuis (H. parasuis) causes exudative inflammation, implying endothelial dysfunction during pathogen infection. However, so far, the molecular mechanism of endothelial dysfunction caused by H. parasuis has not been clarified. By using the transwell-based cell co-culture system, we demo...
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A retrospective analysis of the prognostic implications of glycemic variability on all-cause mortality in critically ill patients with mitral valve disease
Опубликовано 2025-07-01Полный текстBackgroundMitral valve disease is associated with higher cardiovascular morbidity and mortality. Glycemic variability (GV), reflecting blood glucose fluctuations, acts as an independent indicator for results in critically ill patients. However, it’s effect on patients in the ICU with mitral valve di...
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Research progress on the breeding of japonica super rice varieties in Jiangsu Province, China
Опубликовано 2017-05-01Полный текстIn this study we report the results of a decade-long breeding program for japonica super rice made by Nanjing Branch of Chinese National Center for Rice Improvement in Jiangsu Academy of Agricultural Sciences. We concluded that selection of parents with good comprehensive traits and complementary ad...
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A single immunization with core–shell structured lipopolyplex mRNA vaccine against rabies induces potent humoral immunity in mice and dogs
Опубликовано 2023-12-01Полный текстThe persistence and clinical consequences of rabies virus (RABV) infection have prompted global efforts to develop a safe and effective vaccines against rabies. mRNA vaccines represent a promising option against emerging and re-emerging infectious diseases, gaining particular interest since the outb...
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β‐Glucuronidase‐Expressing Lactobacillus reuteri Triggers Irinotecan Enterotoxicity Through Depleting the Regenerative Epithelial Stem/Progenitor Pool
Опубликовано 2025-07-01Полный текстAbstract Irinotecan (CPT11)‐induced diarrhea affects 80–90% of cancer patients due to β‐glucuronidase (GUS) converting 7‐ethyl‐10‐hydroxycamptothecin glucuronide (SN38G) to 7‐ethyl‐10‐hydroxycamptothecin (SN38). It remains unclear whether SN38 impacts the homeostasis between gut microbiota and mucos...
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The P2X7 receptor in depression: Novel insights and therapeutic implications
Опубликовано 2025-09-01Полный текстMajor depressive disorder (MDD) is a heterogeneous mental disorder involving multiple pathogenic mechanisms. Current first-line antidepressant medications suffer from slow onset of action, limited effectiveness, and high side effects, necessitating the search for new therapeutic targets. Targeting c...
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OsWRKY72 enhances salt tolerance in rice via SKC1-mediated Na+ regulation
Опубликовано 2025-09-01Полный текстSoil salinity threatens crop yields, but the molecular basis of crop tolerance to salt stress remain not fully understood currently. This study establish OsWRKY72 enhances salt tolerance in rice via SKC1-mediated Na+ regulation. As a group IIc WRKY transcription factor, OsWRKY72 does not possess can...
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