Zoekresultaten - Ling Ding
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Crossing the Blood–Brain Barrier: Innovations in Receptor- and Transporter-Mediated Transcytosis Strategies
Gepubliceerd in 2025-05-01Volledige tekstThe blood–brain barrier (BBB) is a highly selective and natural protective membrane that restricts the entry of therapeutic agents into the central nervous system (CNS). This restrictive nature poses a major challenge for pharmacological treatment of a wide range of CNS disorders, including neurodeg...
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Effect of Graphene Content on Structure and Glossiness of PU/CuCoating Sprayed on Photovoltaic Panel Surface
Gepubliceerd in 2021-08-01Volledige tekst In order to improve the surface energy absorption performance of photovoltaic panels, the graphene-modified PU/Cu coating was sprayed on the surface of photovoltaic panel. The influence of graphene content on the structure and glossiness of coating was analyzed by SEM observation and glo...
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Transcriptomic and Proteomic Analyses Provide Insight into Sugar Metabolism-Induced Dormancy Release of Flower Buds of <i>Pyrus pyrifolia</i> ‘Cuiguan’
Gepubliceerd in 2025-07-01Volledige tekstPear buds exhibit inherent dormancy, during which carbohydrates play a pivotal role in dormancy release and germination. In this study, <i>Pyrus pyrifolia</i> ‘Cuiguan’ was employed as the experimental material to investigate the molecular mechanisms underlying flower bud dormancy releas...
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Association between oxidative balance score and osteosarcopenia in US adults: insights from a population-based study
Gepubliceerd in 2025-07-01Volledige tekstBackgroundSarcopenia and osteoporosis are interrelated conditions that significantly contribute to adverse health outcomes. Both conditions are negatively influenced by oxidative stress. While antioxidant supplementation has been explored as a potential intervention, its efficacy remains inconsisten...
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KSHV reprograms host RNA splicing via FAM50A to activate STAT3 and drive oncogenic cellular transformation
Gepubliceerd in 2025-07-01Volledige tekstABSTRACT RNA alternative splicing is a fundamental cellular process implicated in cancer development. Kaposi’s sarcoma-associated herpesvirus (KSHV), the etiological agent of multiple human malignancies, including Kaposi’s sarcoma (KS), remains a significant concern, particularly in AIDS patients. A...
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Discovery and Biosynthesis of Nyuzenamides D and E by Genome Mining in Streptomyces hygroscopicus
Gepubliceerd in 2025-06-01 Volledige tekst
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Long-term treatment with benzodiazepines and related Z-drugs exacerbates breast cancer: clinical evidence and molecular mechanisms
Gepubliceerd in 2025-06-01Volledige tekstAbstract Background Benzodiazepines (Diazepam) and related Z-drugs (Zolpidem), henceforth referred to as BZDRs, are widely used for clinical treatment of insomnia and anxiety disorders. BZDRs act on GABA type A receptors to inhibit neurotransmitters. We previously demonstrated that prolonged clinica...
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Efficacy and safety of intensive triglyceride-lowering therapy on reducing recurrence of hypertriglyceridemia-associated pancreatitis (REDUCE): protocol for a multicentre, randomis...
Gepubliceerd in 2025-07-01Volledige tekstIntroduction Recurrence of hypertriglyceridaemia-associated acute pancreatitis (HTG-AP) is common. Uncontrolled HTG after hospital discharge is an important risk factor for recurrence. However, the optimal triglyceride (TG) goal of lipid-lowering therapy for outpatients remains unclear. The efficacy...
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