Search Results - Likun Wang

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    Effect of miR-21 on apoptosis in hepatoblastoma cell through activating ASPP2/p38 signaling pathway in vitro and in vivo

    Effect of miR-21 on apoptosis in hepatoblastoma cell through activating ASPP2/p38 signaling pathway in vitro and in vivo by Lili Liu, Likun Wang, Xidong Li, Ping Tian, Hao Xu, Zenglian Li, Enqin Liu

    Published 2019-12-01

    The objective of this study was to investigate the mechanism underlying miR-21-associated apoptosis in HB. In this study, HB and adjacent tissues were collected from patients with HB. RT-PCR, FISH, western blot, apoptosis assay, migration, invasion and wound healing assays, caspase activity assay, l...

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    Manganese suppresses tumor growth through hyper-activating IRE1α

    Manganese suppresses tumor growth through hyper-activating IRE1α by Ruoxi Shi, Ming Wang, Si Chen, Xinwei Hu, Xudong Zhao, Shixin Zhou, Congli Fan, Zihan Zhou, Likun Wang

    Published 2025-08-01

    Summary: IRE1α and its downstream XBP1 signal is the most conserved unfolded protein response pathway that cells utilize to combat endoplasmic reticulum stress, also known to be utilized by tumor cells to adapt to harsh environment, leading to tumor progression. Several inhibitors against IRE1α have...

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