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    The pseudokinase MLKL contributes to host defense against Streptococcus pluranimalium infection by mediating NLRP3 inflammasome activation and extracellular trap formation

    The pseudokinase MLKL contributes to host defense against Streptococcus pluranimalium infection by mediating NLRP3 inflammasome activation and extracellular trap formation de réir Yu-Xin Lei, Yang Liu, Li-Hua Xing, Yu-Jing Wu, Xue-Yin Wang, Fan-Hua Meng, Ya-Nan Lou, Zhao-Guo Ma, Lin Yuan, Shui-Xing Yu

    Foilsithe / Cruthaithe 2023-12-01

    Host innate immunity plays a pivotal role in the early detection and neutralization of invading pathogens. Here, we show that pseudokinase mixed lineage kinase-like protein (MLKL) is required for host defence against Streptococcus pluranimalium infection by enhancing NLRP3 inflammasome activation an...

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