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    Light Chain Isotype and Antibody-Specificity Impact on Virus Neutralization

    Light Chain Isotype and Antibody-Specificity Impact on Virus Neutralization av Lin Sun, Roman Palt, Georg Schütz, Esther Föderl-Höbenreich, Laura Brod, Antonia Hermle, Anja Lux, Herta Steinkellner, Somanath Kallolimath

    Publicerad 2025-06-01

    Therapeutic antibodies with lambda light chains (λ-Abs) are underrepresented compared to kappa light chains (κ-Abs). Here, we evaluated two SARS-CoV-2-specific monoclonal antibodies (mAbs) that exhibit high (P5C3) and low (H4) antigen binding as κ and λ variants. mAbs expressed in glycoengineered &l...

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