Zoekresultaten - L. V. Topchieva

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  1. 1
    The relationship of the carriership of allelic variations in rs2228145 (A > C) of the<i>IL6R</i> gene with the levels of <i>VCAM1</i> and <i>ICAM1</i> gene transcripts in patients with essential hypertension

    The relationship of the carriership of allelic variations in rs2228145 (A > C) of the<i>IL6R</i> gene with the levels of <i>VCAM1</i> and <i>ICAM1</i> gene transcripts in patients... door L. V. Topchieva, V. A. Korneva, I. V. Kurbatova

    Gepubliceerd in 2020-03-01

    The levels of plasma interleukin 6 and its soluble receptors were found to be elevated in subjects with cardiovascular diseases, which points to amplification of the IL-6-mediated trans-signaling pathway in cells and the development of chronic inflammation. The allelic variation in the rs2228145 IL6...

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  2. 2
    FOXP3, IL2R, CD8A and RORγ gene expression in peripheral blood leukocytes of healthy people and patients with arterial hypertension

    FOXP3, IL2R, CD8A and RORγ gene expression in peripheral blood leukocytes of healthy people and patients with arterial hypertension door L. V. Topchieva, V. A. Korneva, I. E. Malysheva

    Gepubliceerd in 2022-04-01

    Impaired balance of T regulatory and T effector lymphocytes has recently been considered as an important pathogenetic link in arterial hypertension (AH). There are, however, contradictory literature data about contents of these cells in the patients with hypertension, or obtained in experimental ani...

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  3. 3
    Association between Arg753Gln (rs574308) polymorphism of the Toll-like receptor 2 (TLR2) gene and the risk of pulmonary sarcoidosis among the residents of Karelia”

    Association between Arg753Gln (rs574308) polymorphism of the Toll-like receptor 2 (TLR2) gene and the risk of pulmonary sarcoidosis among the residents of Karelia” door I. E. Malysheva, L. V. Topchieva, E. L. Tikhonovich

    Gepubliceerd in 2022-07-01

    Genetic factors play an important role in the development and progression of many disorders including lung sarcoidosis which is a systemic inflammatory granulomatous disease of unknown etiology, characterized by the formation of epithelioid cell granules in affected tissues. Intensity of the develop...

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  4. 4
    ASSOCIATION OF rs4537545 (C>T) ALLELE POLYMORPHISM IN THE IL6R GENE WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS

    ASSOCIATION OF rs4537545 (C>T) ALLELE POLYMORPHISM IN THE IL6R GENE WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS door L. V. Topchieva, I. E. Malysheva, O. V. Balan, I. M. Marusenko, O. Yu. Barysheva

    Gepubliceerd in 2020-06-01

    Objective: to analyze the association of the polymorphic marker rs4537545 (C&gt;T) in the IL6R gene with the development of rheumatoid arthritis (RA) in the population of the Republic of Karelia. Subjects and methods. The investigation included 190 samples of DNA extracted from the whole blood o...

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  5. 5
    Macrophage polarization in sarcoidosis

    Macrophage polarization in sarcoidosis door I. E. Malysheva, E. L. Tikhonovich, E. K. Oleinik, L. V. Topchieva, O. V. Balan

    Gepubliceerd in 2021-03-01

    Sarcoidosis is a systemic inflammatory disease of unknown etiology, characterized by the formation of epithelioid cell granulomas, multisystem lesions with a certain frequency of involvement of various organs, mainly the lungs (up to 90% of cases). Over the past decade, significant progress has been...

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