Rezultaty - L. N. Lyubchenko

Introduction. Malignant tumor is one of the leading factors of venous and arterial thrombosis. But there is no data on the need for a genetic testing protocol of cancer patients for genetic predisposition thrombotic conditions, despite the fact that a number of polymorphisms of hemostasis genes are...

Szczegółowa specyfikacja

Background. Ischemic stroke is one of the most frequent causes of postoperative death in patients with thoracoabdominal malignant tumors. The role of molecular genetic factors of cardiovascular risk in the development of this complication in cancer patients has not yet been studied properly. The ide...

Szczegółowa specyfikacja

With conventional approaches to mammography tissue examination in women over 40 years of age, mammography has been found to be lesseffective for a group of younger women with negative family histories (cancer in the family) and BRCA1 and BRCA2 gene mutation carriers.A distinct approach to mammograph...

Szczegółowa specyfikacja

Objective: to conduct a systematic literature review of the published studies on retroperitoneal non-organ liposarcomas.Material and Methods. A literature search was performed using Pubmed, Elibrary, COSMIC databases. The data of retrospective and prospective clinical trials were analyzed. Results....

Szczegółowa specyfikacja

Lynch syndrome was synonymous with hereditary non-polyposis colorectal cancer for a long time, however, mapping of the DNA mismatch repair (MMR) genes has led to distinguish Lynch syndrome as an independent syndromic unit from a number of Lynch-like syndromes that phenotypically mimic with the most...

Szczegółowa specyfikacja

Objective. Early-onset gastric cancer (EOGC) constitutes a serious medical and social problem. Early-onset gastric cancer accounts for approximately 6% of all malignant epithelial neoplasms.Material and Methods. We reviewed retrospective and prospective randomized trials using Medline and Elibrary d...

Szczegółowa specyfikacja

Uveal melanoma (UM) is the most common primary intra-ocular malignancy. Uveal melanoma is distinct from other subtypes of melanoma by its molecular and genetic characteristics. Somatic mutations in UM tumor involve genes, such as BAP1, EIF1AX, GNA11, GNAQ and SF3B1, that determine the biology and be...

Szczegółowa specyfikacja

Objective. Unlike genetic changes, epigenetic aberrations in prostate cancer can be reversed under the influence of a chemical agent. This fact makes the study of epigenetic changes an important object as potential therapeutic targets. Material and methods. PubMed, Medline, eLibrary.ru databases wer...

Szczegółowa specyfikacja

The study has demonstrated that medical abortion in women with a history of breast cancer is not justified as a medical intervention in further pregnancy. After 2 years of the termination of treatment, there may be procreation in a patient with early cancer, a good prognosis, and an active wish to h...

Szczegółowa specyfikacja

Objective: to detect new molecular genetic markers and therapeutic targets in retroperitoneal myxoid liposarcoma.Material and Methods. DNA samples isolated from tumor tissue and obtained from formalinfixed paraffin-embedded (FFPE) slides were used. DNA was extracted using the GeneRead DNA FFPE Kit (...

Szczegółowa specyfikacja

Eleven cases of breast cancer (BC) diagnosed during or after in-vitro fertilization (IVF) are considered. The study group was observed to have cases of familial BC in 18.2% of the patients and BRCA1 gene mutations in 60%. At the same time 45.5% of cases had local- ly advanced and generalized BC, whi...

Szczegółowa specyfikacja

Screening of breast cancer with mammography recommended to women over 40 has been shown to decrease breast cancer mortality. But mam- mography has much lower accuracy in young women with BRCA1/2 mutations and women with a strong family history. Therefore new screening methods in young high-risk wome...

Szczegółowa specyfikacja

For patients with an identified germline E-cadherin-1 (CDH1) mutation, prophylactic gastrectomy is the treatment of choice to eliminate the high risk of developing diffuse gastric  cancer. The case report describes a rare case of hereditary diffuse gastric cancer (HDGC)  associated with CDH1 gene mu...

Szczegółowa specyfikacja

During last years one should note an unstoppable increase of the breast cancer incidence among patients of reproductive age. A group of pa- tients of young age with the breast cancer whose disease is associated with the BRCA1/2 genes is of particular scientific interest. However, until now no single...

Szczegółowa specyfikacja

The problems in the early diagnosis, primary and secondary prevention of family cancer of the breast and/or ovaries are successfully solved within medical genetic counseling at a cancer clinic. Its genetic diagnosis is confirmed, individual risks for breast and/or ovarian cancer are calculated, risk...

Szczegółowa specyfikacja

Brodie’s tumors are comparatively rare in oncological care and difficult-to-diagnose masses with an unpredictable course, predilection for recurrences, and a high probability of malignization. These tumors have a two-component structure with the predominant develop- ment of a connective tissue compo...

Szczegółowa specyfikacja

Background. According to literature data, errors in the diagnosis of gastrointestinal tumors (GIST) are uncommon, accounting for approximately 6% of cases that results in treatment failure. Case report. Here, we describe a rare case of a 58-year-old female patient with extragastrointestinal stromal...

Szczegółowa specyfikacja

MEN 2B syndrome is a subtype of the multiple endocrine neoplasia type 2. It is characterized by the development of aggressive forms of medullary thyroid cancer at an early age, pheochromocytoma and hyperparathyroid syndrome. This article provides an own clinical observation of the patient with MEN 2...

Szczegółowa specyfikacja

A group of reproductive age patients whose disease is associated with the carriage of BRCA1 gene mutation is of scientific interest. Differences in the molecular pathogenesis between BRCA-associated breast cancer and sporadic counterpart might presuppose anamnesis features of each group as well. We...

Szczegółowa specyfikacja

Particular emphasis has been recently placed on the mechanisms of carcinogenesis in breast cancer (BC), including those in male BC. The paper describes the major risk factors for BC in male patients and covers the role of BRCA1 and BRCA2 gene mutations in the occurrence of this pathology. The most i...

Szczegółowa specyfikacja