Risultati della ricerca - L. G. Goryacheva
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Modern concepts on pathogenetic mechanisms of liver fibrosis
Pubblicazione 2023-04-01TestoThis review summarizes current data on the pathogenetic mechanisms of fibrosis in chronic liver diseases. Controlled inflammation and transdifferentiation of hepatic stellate cells into myofibroblasts is a key element of fibrogenesis, however, further study of the role of each of the macrophage popu...
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HBV - infection in children with perinatal infection. Clinical report of familial hepatitis B
Pubblicazione 2021-10-01TestoHepatitis B, despite of being a controlled infection today, is one of the most common form of hepatitis in the world. According to the experts' evaluation there are about 3 million patients with chronic hepatitis B in our country. The global strategy of the World Health Organization includes th...
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ORGANIZATION OF MEDICAL AID DURING ANTHRAX OUTBREAK IN YAMALO-NENETS AUTONOMOUS DISTRICT IN 2016
Pubblicazione 2017-03-01TestoThe efficiency and timeliness of medical care of infectious patients are largely determined by the promptness of diagnosis and the rational organization of medical sorting of patients and contact persons. In 2016 there were 36 anthrax cases in the Yamal. In the immediate area of the epidemic were 32...
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Rational Pharmacotherapy and Correction of Immunity Disorders in Children with Chronic Hepatitis (Clinical Review)
Pubblicazione 2020-05-01TestoThe data on the efficacy of antivirals and their impact on the virologic and immunologic indices in HCV- and HBV-infected children are presented. The best therapeutic effect in the management of children with chronic virus hepatitis was provided by combined antiviral therapy of different action. In...
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Cycloferon Efficacy in Viral and Bacterial Diseases of Children (Clinical Review)
Pubblicazione 2020-05-01TestoThe authors' findings and literature data on the pharmacotherapeut efficacy of cycloferon, an interferon inductor (immunomodulators) are described. The drug effect in the treatment of various socially significant children' diseases, including acute respiratory tract viral infection, bronch...
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Liver elastography in children practice
Pubblicazione 2014-09-01TestoWe anylised results of elastography of 77 patients with chronic liver diffus lesions including: viruses hepatitis B, C, D – 50, autoimmune – 16, metabolic disease – 6, neonatal hepatities – 5 persons. Fibrosis stage was assessed on METAVIR scail. For patients with viruses hepatitis B, C with an aver...
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Family hemophagocytic lymphohistiocytosis: (2 clinical cases in one family)
Pubblicazione 2019-10-01TestoFamily hemophagocytic lymphohistiocytosis (hemophagocytic syndrome) is a rare hereditary disease, which is based on a disturbance of the regulation of the immune response, leading to proliferation and activation of histiocytes, phagocytosis of peripheral blood cells. The most common mutations includ...
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Features of the course and outcomes of neonatal hepatitis of various etiologies
Pubblicazione 2014-09-01TestoWe have performed primary examination of 50 children with neonatal hepatitis. Prevalence of herpes infection as the etiologic agent (40,0%) has been found, as well as parenteral hepatitis, both as an isolated (26,0%) and mixed infections. We conducted a comparative analysis of clinical and laborator...
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Minimization of Endogenous Intoxication Syndrome by Individual Choice of Drugs for Therapy of Chronic Hepatitis
Pubblicazione 2020-05-01TestoThe results of clinical and laboratory examination of 107 children suffering from chronic hepatitis B or C were analysed. The biochemical criteria of the endogenous intoxication were investigated. Specific blood tests with antiviral drugs were conducted before the treatment and individual therapy sc...
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Viral Hepatitis A-associated with an aplastic anemia at a child 5 years old (clinical observation)
Pubblicazione 2014-09-01Testo.
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New diagnostic and treatment perspectives of children’s hepatic lesions
Pubblicazione 2014-09-01TestoThis review presents the current possibilities of diagnosis of children’s liver disease: to define avidity of antibodies to hepatitis A, C for detection early infection, the development of non-invasive panel of serum markers of fibrosis and the introduction of elastography liver, as an alternative t...
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CLINICAL FEATURES OF ANTHRAX MANIFESTATIONS IN YAMALO-NENETS AUTONOMOUS DISTRICT IN 2016
Pubblicazione 2017-03-01Testo36 cases of human infection with anthrax, manifested in various clinical forms, were registered in the territory of Yamalo-Nenets Autonomous District in 2016. Cutaneous anthrax was characterized by emergence of carbuncle, however objective difficulties of clinical diagnostics, associated with atypic...
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Cycloferon Efficacy of Therapy of Chronic Hepatitis B (Results of Randomized Multicentre Study)
Pubblicazione 2020-05-01TestoThe best therapeutic effect in the treatment of patients with chronic hepatitis B was observed with the use of cycloferon in the scheme of the antiviral therapy. The combination of cycloferon with lamivudine provided complete stable remission in 54.1% of the patients, whereas the use of а-interferon...
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Pathogenetically Substantiated Therapy of Patients with Virus Hepatitis C, the Life Quality and the Disease Outcome Risk (Clinical Survey)
Pubblicazione 2020-05-01TestoThe aspects of virus hepatitis C immunopathogenesis are discussed. The main attention is paid to higher production of Th1 cytokines providing active protection of the host from HCV. The up-to-date approaches to the therapy of chronic hepatitis C, described in the literature and the original ones, in...
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A case of severe acute hepatitis of unknown etiology requiring liver transplantation in a child with adenovirus infection
Pubblicazione 2022-07-01TestoThe article presents a clinical observation of severe acute hepatitis of unknown aetiology with liver transplantation in a 16-year-old child, which occurred in October 2021. Initial symptoms were abdominal pain, diarrhea. The general wellbeing of the girl did not suffer, there was no fever, no intox...
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