Search Results - L S Snegireva
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How to identify a patient with autoinflammatory syndrome: Clinical and diagnostic algorithms
Published 2013-10-01Get full textAutoinflammatory syndromes (AISs) are a group of predominantly hereditary diseases associated with the spontaneous uncontrolled production of proinflammatory cytokines. Most diseases are known to have molecular mechanisms and an inheritance pattern. The paper describes major AISs, such as familial M...
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Evaluation of the efficiency and safety of tocilizumab therapy in patients with systemic-onset juvenile idiopathic arthritis: results of a retrospective follow-up
Published 2018-01-01Get full textObjective: to study the efficiency and safety of tocilizumab (TCZ) therapy in patients with systemic-onset juvenile idiopathic arthritis (sJIA). Patients and methods. The retrospective study included 48 children with active sJIA in whom TCZ therapy was initiated because of the inefficiency of using...
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Current approaches to diagnosing and treating macrophage activation syndrome in children with rheumatic diseases
Published 2015-03-01Get full textMacrophage activation syndrome (MAS) is a severe life-threatening complication presenting with hemophagocytosis, pancytopenia, coagulopathy, and liver and CNS dysfunctions. The disease belongs to a group of histiocytic disorders. The common triggers for MAS are rheumatic diseases, particularly syste...
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Primary idiopathic hypertrophic osteoarthropathy in a child: characteristics of the disease with a case report
Published 2018-01-01Get full textThe paper gives the data available in the literature on the relatively rare disease hypertrophic osteoarthropathy (HOA). This syndrome includes symptoms, such as clubbed fingers (hypertrophy of the distal phalanges), periostosis (subperiosteal new bone formation along the distal diaphysis of the lon...
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The Efficiency of Adalimumab in Cases of Chronic Methotrexate-Resistant Juvenile Idiopathic Arthritis-Associated Anterior Uveitis: Retrospective Case Series Study
Published 2016-11-01Get full textBackground: Juvenile idiopathic arthritis (JIA) associated uveitis may be the cause of not only visual acuity decrement, but also blindness. At the same time, in some patients therapy with methotrexate can not prevent the development of these complications.Objective: Our aim was to investigate the e...
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Invasive fungal infections in children with rheumatic diseases
Published 2021-01-01Get full textIntroduction. In children with rheumatic diseases, severe fungal infections (invasive mycoses – IM) are not well understood.Objectives. To analyze risk factors, disease course of IM in children with systemic rheumatic diseases.Materials and methods. For diagnosis of IM were used criteria EORTC/MSGER...
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Comparison of different treatment modalities of tocilizumab in children with systemic juvenile idiopathic arthritis
Published 2013-09-01Get full textAim: to perform retrospective evaluation of tocilizumab (TCZ) treatment every 2 and 4 weeks. Patients and methods: 33 children with systemic juvenile idiopathic arthritis (sJIA) were observed. Results: children, who need TCZ treatment every 2 weeks had more severe sJIA course. Patients which were tr...
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Can the Methotrexate Therapy Prevent the Development of Uveitis in Patients with Juvenile Idiopathic Arthritis: Results of a Retrospective Study
Published 2015-09-01Get full textBackground: Uveitis is one of the most common extra-articular manifestations of juvenile idiopathic arthritis (JIA). Currently, the possibility of reducing the risk of uveitis in children with JIA by using methotrexate has been studied.Objective: Our aim was to analyze the results of treatment of ch...
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Differences of hip involvement in systemic and non-systemic juvenile idiopathic arthritis
Published 2022-03-01Get full textSystemic corticosteroids are continued to be administered in juvenile idiopathic arthritis (JIA) patients, especially in systemic JIA (sJIA), despite the ability of biologic therapy. One of the complications of long-term CS treatment is delayed hip arthritis development with risk of secondary hip os...
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