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    Identification of the seven critical residues that control ZIKV-DENV cross-reactivity to engineer a non-cross-reactive ZIKV vaccine

    Identification of the seven critical residues that control ZIKV-DENV cross-reactivity to engineer a non-cross-reactive ZIKV vaccine af Ariadna Grinyo-Escuer, Srikar Reddy, Agnes L. Chenine, J. Charles Whitbeck, Sonya Jacobsen, Allison Sheetz, Kyle Doolan, Diana M. Norden, Nolan Frey, Frederick W. Holtsberg, M. Javad Aman, Katja Fink, Michael S. Diamond, John S. Schieffelin, James E. Crowe, Jr., Edgar Davidson, Benjamin J. Doranz

    Udgivet 2025-08-01

    Summary: The development of a Zika virus (ZIKV) vaccine is complicated by the high homology between ZIKV and dengue virus (DENV) envelope (E) proteins, resulting in immunological cross-reactivity that can exacerbate disease through antibody-dependent enhancement (ADE). Here, we screen 121 anti-DENV...

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