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    AAV6 vectors provide superior gene transfer compared to AAV9 vectors following intramyocardial administration

    AAV6 vectors provide superior gene transfer compared to AAV9 vectors following intramyocardial administration by Jianan Wang, Timo Jonker, Aina Cervera-Barea, Zhenyu Dong, Ruud N. Visser, Evelien E. Birza, Arie R. Boender, Mischa Klerk, Yuting Yang, Joyce Visser, Marlijn S. Jansen, Tom C. Grootswagers, Cindy I. Bart, Saskia C.A. de Jager, Silke Schrödel, Christian Thirion, Osne F. Kirzner, Hanno L. Tan, Antoine A.F. de Vries, Joost P.G. Sluijter, Klaus Neef, Joris R. de Groot, Vincent M. Christoffels, Gerard J.J. Boink

    Published 2025-09-01

    Cardiac gene therapy using adeno-associated viral (AAV) vectors holds great promise for treating heart diseases but would benefit from more potent AAV vectors. Vectors based on the AAV serotypes 6 and 9 have been used in pre-clinical gene therapy studies, yet the therapeutic outcomes varied dependin...

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