検索結果 - Kenneth W. Witwer

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  1. 1
    Defining the Parameters for Sorting of RNA Cargo Into Extracellular Vesicles

    Defining the Parameters for Sorting of RNA Cargo Into Extracellular Vesicles 著者: Ahmed Abdelgawad, Yiyao Huang, Olesia Gololobova, Yanbao Yu, Kenneth W. Witwer, Vijay Parashar, Mona Batish

    出版事項 2025-07-01

    ABSTRACT Extracellular vesicles (EVs) are small particles that are released by cells and mediate cell–cell communication by transferring bioactive molecules such as RNA. RNA cargo of EVs, including coding and non‐coding RNAs, can change the behaviour of recipient cells, affecting processes including...

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    Plasma extracellular vesicle surface-located GAS6/PROS1 and CD39/CD73 attenuate inflammation

    Plasma extracellular vesicle surface-located GAS6/PROS1 and CD39/CD73 attenuate inflammation 著者: Martina P. Fabiano, Alan M. Adamczyk, Olesia A. Gololobova, Ignacio G. Mazzitelli, María L. Leicaj, Tomás M. Grosso, Paula S. Pérez, Cora L. Alvarez, Julieta Schachter, Silvina Palmer, Florencia Sabbione, Fernando A. Erra Díaz, Analía S. Trevani, Manuel Varas-Godoy, Eugenio A. Carrera Silva, Kenneth W. Witwer, Matías Ostrowski

    出版事項 2025-08-01

    Summary: Herein, we demonstrate that extracellular vesicles (EVs) present in healthy human plasma regulate macrophage activation by triggering MERTK-dependent signaling in a growth arrest-specific 6 (GAS6)- and protein S (PROS1)-dependent manner. Moreover, EVs regulate oxidative burst and degranulat...

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