Search Results - K. I. Zhordania

The paper considers some pathogenetic aspects of ovarian tumor development, on the basis of which the authors recommend to perform more aggressive chemotherapy in patients with the so-called early stages of ovarian cancer.

Aim: to identify clinical and histologic features of pure stromal ovarian tumors.Materials and methods. We analyzed the clinical data from patients treated and followed up at the Blokhin National Medical Research Center of Oncology and the National Center of Oncology and Hematology of the Kyrgyz Rep...

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Advances made in oncogynecology and improvements of surgical, radiation, and drug treatment provided relatively good sur- vival rates in patients with female genital organ lesions. However, this treatment often leads to postcastration syndrome mani- festations in most young women. New rehabilitation...

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Aim: to identify clinical and histological criteria for sex cord ovarian stromal tumors (OSTs).Materials and Methods. The retrospective non-comparative study was based on the main inclusion such as histologically verified sex cord OSTs. A standard examination algorithm was analyzed (ultrasound, bloo...

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The specific features of the expression of tumor-associated proteins (TAP) were immunologically studied in the sera of patients with ovarian cancer (OC) and other tumor location by means of immune sera (As) or monoclonal antibodies (MAb) to find out whether they could be used to diagnose and estimat...

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With the help of monoclonal antibodies (MCA-1, MCA-3, G1 class immunoglobulins) and polyspecific antiserum (As) by means of immunoblotting (IB) the increase of the expression of the tumor-associated proteins (TAP) in the samples of the tumor tissues (in 94, 55 and 38% respectively), metastatic lymph...

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The prevention of cancer of the cervix uteri (CCU) is an interdisciplinary problem that may be solved only via joint efforts of gynecol- ogists, oncologists, virologists, and immunologists. Since there is currently strong evidence for the viral origin of CCU, vaccination is prominent in its primary....

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Social rehabilitation in patients who have been treated for malignancies of different sites and stages becomes a particularly urgent problem today and its solution is one of the promising areas of oncology. The important stage of this rehabilitation that seems to us is to maintain or recover their r...

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Adenosquamous cell carcinoma of the cervix is a rare form of cancer of the cervix. Because of the small number of observations adenosquamous cell carcinoma of the cervix remains poorly understood disease, although the first mention of it dates back to 1956, when A. Glucksmann, and C.D. Cherry first...

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Leiomyomas predominate among benign nonepithelial tumors of the corpus uteri. Leiomyoma is commonly an asymptomatic tumor and detectable in most cases at routine gynecological examinations. However, some forms of leiomyomas have a definite metastatic potential and, despite its benign morphological s...

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Leiomyomas predominate among benign nonepithelial tumors of the corpus uteri. According to the data available in the literature, they occur in 25% of women above 35 years of age and constitute 33% of all gynecological diseases. Leimyoma is commonly an asymptomatic tumor and detectable in most cases...

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Proteomics has recently found wide application to account for the molecular mechanisms of cancer and to search for biomarkers that may be used to diagnose and/or predict the development of the disease. The paper briefly reviews proteomic studies to detect ovarian cancer biomarkers, by taking into ac...

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Introduction. Despite that ovarian carcinosarcoma (OCS) is an extremely rare disease, it is of great medical and social importance by taking into account very high level of overall mortality, recurrence, metastasis, and economic costs.Aim: to summarize current data on various aspects of OCS.Material...

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Early diagnosis of recurrent ovarian granulose cell tumors (OGCT) remains an urgent problem of modern oncogynecology. Inhibin B is one of the most potentially important markers of OGCT. Nevertheless, in the world there are today only single studies evaluating the clinical value of inhibin B. The pap...

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The proteome of ascites and pleural fluids (AF and PF) was mapped in patients with ovarian cancer (OC). 240 and 190 proteins were identi- fied with a high degree of assurance in A F and PF, respectively . The major portion w as extracellular and membrane proteins, whi ch ac- counted for 45 and 49 %...

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The paper considers the clinical picture, diagnosis, mechanisms of development, and prognosis of ovarian malignancies and polyneoplasias in detail. The purpose of the investigation was to study the clinical features of polyneoplasms with the involvement of the ovaries and to define the ways of impro...

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At present, there is no screening test for the early detecting and monitoring of ovarian cancer, one of the most lethal form of gynaecological malig- nancy in the worldwide. In this study, the new methodology for the search of tumor markers of ovarian cancer, involving profiling the low-molec- ular...

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Objective: to study the pathomorphological signs of pure and mixed clear-cell ovarian tumors with a clear-cell component.Subjects and methods. The clinical and morphological characteristics and the course of the disease were analyzed in 96 patients aged 21 to 75 years with clear-cell ovarian carcino...

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Ovarian cancer (OC) is characterized by its late diagnosis, mainly local tumor dissemination within the abdomen and small pelvis, and a relatively high susceptibility to drug therapy . Intraabdominal chemotherapy (CT) allows the higher intraabdominal drug concentrations to be produced as compared to...

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Recurrent ovarian granulose cell tumors (OGCT) occur in 20-40% of cases. The low incidence of OGCT and the specific features of their clinical course highly hamper the study of the mechanisms of development of recurrences and the possibilities of timely detection of disease progression and the deter...

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