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    TLR4 interaction with PIEZO1 facilitates the 5-HT-mediated intestinal motility dysfunction in offspring mice induced by LPS exposure during pregnancy

    TLR4 interaction with PIEZO1 facilitates the 5-HT-mediated intestinal motility dysfunction in offspring mice induced by LPS exposure during pregnancy by Ruifang Luo, Yuan Miao, Riqiang Hu, Fang Lin, Junyan Yan, Ting Yang, Lu Xiao, Zhujun Sun, Yuting Wang, Jie Chen

    Published 2025-09-01

    Several factors during pregnancy, such as changes in serotonin (5-HT) levels, can affect intestinal function in offspring mice. The role of 5-HT in regulating intestinal motility after lipopolysaccharide (LPS) exposure during pregnancy is unclear. In this study, Tlr4fl/fl and Tlr4▵IEC mice were inje...

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