Search Results - Junwei Luo

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    The insulator EACBE regulates V(D)J recombination of Tcrd gene by modulating chromatin organization

    The insulator EACBE regulates V(D)J recombination of Tcrd gene by modulating chromatin organization by Yongchang Zhu, Yongchang Zhu, Ranran Dai, Ranran Dai, Hao Zhao, Junwei Luo, Keyi Li, Wei Xue, Litao Qin, Hongyuan Pan, Shixiu Liao, Bingtao Hao, Bingtao Hao

    Published 2025-07-01

    T cell receptor (TCR) diversity, essential for the recognition of a wide array of antigens, is generated through V(D)J recombination. The Tcra and Tcrd genes reside within a shared genomic locus, with Tcrd rearrangement occurring first in the double-negative (DN) stage during thymocyte development....

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