Search Results - Jun Tu

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  1. 1
    Determinants of carotid intima-media thickness in patients with asymptomatic unstable plaques: a population-based cross-sectional study in rural China

    Determinants of carotid intima-media thickness in patients with asymptomatic unstable plaques: a population-based cross-sectional study in rural China by Ping Tang, Yuting Lu, Huihui Xue, Juan Hao, Haotian Wen, Jun Tu, Jun Tu, Jun Tu, Jun Tu, Ran Chen, Juan Li, Jinghua Wang, Jinghua Wang, Jinghua Wang, Jinghua Wang, Xianjia Ning, Xianjia Ning, Xianjia Ning, Xianjia Ning, Chunsheng Yang, Yan Li, Lifeng Wang

    Published 2025-07-01

    PurposeStroke remains a leading cause of death and disability worldwide, with carotid intima-media thickness (IMT) and carotid plaque being significant predictors of cerebrovascular diseases. Despite the established correlation between carotid IMT and stroke, the specific factors influencing IMT in...

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  2. 2
    Nanoparticle delivery of VEGF-B mRNA promotes T cell infiltration within tumor and triggers robust antitumor immunity

    Nanoparticle delivery of VEGF-B mRNA promotes T cell infiltration within tumor and triggers robust antitumor immunity by Geqiang Zhang, Jun Tu, Yu Zhang, Jianli He, Guoyuan Peng, Qiuju Fan, Yirong Zhang, Mingming Zhang, Hongsheng Tan, Yingjie Xu, Jinke Cheng

    Published 2025-09-01

    The advancement of mRNA-based cancer immunotherapies has gained significant momentum, particularly after the success of mRNA vaccines during the COVID-19 pandemic and the recognition of mRNA vaccine development with the 2023 Nobel Prize. mRNA encoding cytokines, antibodies, and chimeric antigen rece...

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    Scaffold and SAR studies on c-MET inhibitors using machine learning approaches

    Scaffold and SAR studies on c-MET inhibitors using machine learning approaches by Jing Zhang, Mingming Zhang, Weiran Huang, Changjie Liang, Wei Xu, Jinghua Zhang, Jun Tu, Innocent Okohi Agida, Jinke Cheng, Dong-Qing Wei, Buyong Ma, Yanjing Wang, Hongsheng Tan

    Published 2025-06-01

    Numerous c-mesenchymal-epithelial transition (c-MET) inhibitors have been reported as potential anticancer agents. However, most fail to enter clinical trials owing to poor efficacy or drug resistance. To date, the scaffold-based chemical space of small-molecule c-MET inhibitors has not been analyze...

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