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    Impaired splicing machinery in craniopharyngiomas unveils PRPF8 and RAVER1 as novel biomarkers and therapeutic targets

    Impaired splicing machinery in craniopharyngiomas unveils PRPF8 and RAVER1 as novel biomarkers and therapeutic targets by Antonio C. Fuentes-Fayos, Miguel E. G-García, Teresa Sánchez-Medianero, John Apps, Álvaro Flores-Martínez, Ana S. De la Rosa-Herencia, Ignacio Gil-Duque, Georg Otto, Eva Venegas-Moreno, Eugenio Cárdenas Ruiz-Valdepeñas, Aura D. Herrera-Martínez, Juan Solivera, Manuel D. Gahete, David A. Cano, Rosa Ortega, Alfonso Soto-Moreno, María A. Gálvez-Moreno, Juan Pedro Martínez-Barberá, Raúl M. Luque

    Published 2025-06-01

    Abstract Craniopharyngiomas are rare benign pathologies but clinically challenging tumours because of their intimate relationship with critical brain structures, leading to severe endocrine-deficiencies/comorbidities. Therefore, identifying alternative prognostic/therapeutic tools is crucial. Althou...

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