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Characterization of a STAT-1 Knockout Mouse Model for Machupo Virus Infection and Pathogenesis by Stephanie R. Monticelli, Ana I. Kuehne, Russell R. Bakken, Susan R. Coyne, Kenise D. Lewis, Jo Lynne W. Raymond, Xiankun Zeng, Joshua B. Richardson, Zebulon Lapoint, Jennifer L. Williams, Christopher P. Stefan, Jeffrey R. Kugelman, Jeffrey W. Koehler, Andrew S. Herbert
Published 2025-07-01Machupo virus (MACV), a member of the <i>Arenaviridae</i> family and causative agent of Bolivian hemorrhagic fever, results in lethality rates of 25–35% in humans. Mice lacking the signal transducer and activator of transcription 1 (STAT-1<sup>−/−</sup>) have previously been...
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