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    Targeting Annexin A2 to reactivate tumor-associated antigens presentation and relieve immune tolerance in liver cancer

    Targeting Annexin A2 to reactivate tumor-associated antigens presentation and relieve immune tolerance in liver cancer by Min Li, Hui Shen, Feng Xie, Feng Lu, Jianxin Yang, Yuxiao Tang, Qicong Shen, Zelong Gao, Mengpu Wu, Chenghua Wu, Jicong Du, Changquan Ling, Yifeng Chai, Xin Dong, Jianxin Qian, Chenqi Li, Zhenhong Guo, Dongyao Wang

    Published 2025-06-01

    Background Tumor cells manipulate the tumor-associated antigens presentation to escape immune surveillance; however, the molecular mechanism is not exactly clear and the measure to intervene is missing.Methods Annexin A2 was knockout by the CRISPR-Cas9 or blocked by the small-molecule matrine, PY60,...

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