Search Results - Jianmin Wang
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Mediastinal lymph node dissection versus mediastinal lymph node sampling for early stage non-small cell lung cancer: a systematic review and meta-analysis.
Published 2014-01-01Get full text<h4>Objective</h4>This systematic review and meta-analysis aimed to evaluate the overall survival, local recurrence, distant metastasis, and complications of mediastinal lymph node dissection (MLND) versus mediastinal lymph node sampling (MLNS) in stage I-IIIA non-small cell lung cancer...
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Robustness of ecological indicators to species misidentification in the national forest inventory of the United States
Published 2025-07-01Get full textAbstract Longitudinal data are essential to assessing change in environmental parameters over space and through time. This is particularly true in forest ecosystems where demographic patterns are controlled by many biotic and abiotic factors that may only be observed through repeated measures of tre...
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Shared diagnostic genes and potential mechanisms between intervertebral disc degeneration and diabetes mellitus revealed by integrated transcriptomic analysis and machine learning
Published 2025-07-01Get full textIntroductionIntervertebral disc degeneration (IDD) and diabetes mellitus (DM) are clinically associated beyond traditional risk factors, yet the shared molecular mechanisms remain unclear.MethodsWe integrated transcriptomic data from IDD and DM cohorts, performed differential expression and protein–...
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Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non–small-cell lung cancer
Published 2017-07-01Get full textAcquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors, such as gefitinib and erlotinib, is a critical issue in the treatment of patients with epidermal growth factor receptor mutant–positive non–small-cell lung cancer. Recent evidence suggests that downregulation of gene...
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Diffusion-based generative drug-like molecular editing with chemical natural language
Published 2025-06-01Get full textRecently, diffusion models have emerged as a promising paradigm for molecular design and optimization. However, most diffusion-based molecular generative models focus on modeling 2D graphs or 3D geometries, with limited research on molecular sequence diffusion models. The International Union of Pure...
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Anticancer Quinolinol Small Molecules Target Multiple Pathways to Promote Cell Death and Eliminate Melanoma Cells Resistant to BRAF Inhibitors
Published 2025-06-01Get full textSmall molecule inhibitors that target the E3 ligase activity of MDM2-MDM4 have been explored to inhibit the oncogenic activity of MDM2-MDM4 complex. MMRi62 is a small molecule that was identified using an MDM2-MDM4 E3 ligase-based high throughput screen and a cell-death-based secondary screen. Our p...
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Study on collateral sensitivity of tigecycline to colistin-resistant Enterobacter cloacae complex
Published 2025-07-01Get full textABSTRACT The past decade has witnessed the emergence and spread of carbapenem-resistant Enterobacter cloacae complex (CRECC), presenting a significant clinical challenge and urgently demanding new treatment strategies against antimicrobial resistance (AMR). This study focused on the impact of tigecy...
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Checkpoint immunotherapy is associated with preferential activation of tumor antigen–specific CD4+ T cells in MDS
Published 2025-08-01Get full textAbstract: A growing body of literature suggests that the efficacy of DNA hypomethylating agents are mediated via activation of antitumor immune mechanisms. Based upon this hypothesis, early phase trials combining immune checkpoint inhibitors (ICIs) with azacitidine in patients with myelodysplastic s...
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