Search Results - Jiang Du
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The Interaction of DMRTA2 with HSP90β Inhibits p53 Ubiquitination and Activates the p53 Pathway to Suppress the Malignant Progression of Non-Small-Cell Lung Cancer
Published 2025-06-01Get full text<b>Background:</b> Lung cancer, predominantly NSCLC (80%), has a poor prognosis due to late diagnosis and limited treatment efficacy. <i>DMRTA2 (DMRT5)</i>, a transcription factor linked to neural/germ cell development, is overexpressed in NSCLC per TCGA data, indicating its...
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Alex3 suppresses non–small cell lung cancer invasion via AKT/Slug/E-cadherin pathway
Published 2017-07-01Get full textAlex3, is a newly identified mitochondrial protein, regulates mitochondrial dynamics and is involved in neural development. However, its expression pattern and clinicopathological relevance in human tumors are still unclear. In this study, Immunohistochemistry assay was performed in 109 cases of lun...
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Association of serum Klotho with tinnitus prevalence, duration and severity: A cross-sectional study in middle-aged and older adults.
Published 2025-01-01Get full text<h4>Background</h4>As an anti-aging protein, although studies increasingly suggest that the Klotho plays a role in the auditory system, the link between serum Klotho levels and tinnitus remains poorly characterized. The aim of this study was to investigate the associations between serum...
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Actinium-225-PSMA-617 treatment in a patient with advanced prostate cancer causes secondary myelofibrosis: a case report and literature review
Published 2025-07-01Get full textAdvanced prostate cancer (PCa) is still an incurable disease. Still, the field of PSMA-targeted radioligand therapy is developing rapidly and is playing an increasingly important role in the treatment of advanced Pca in the future. As an α -particle emitter, Ac-225 shows a potent killing ability for...
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Mussel-inspired superhydrophobic coating via self-assembled polydopamine/SiO2 for enhancing the durability of marine concrete
Published 2025-12-01Get full textSuperhydrophobic coatings offer significant potentials for extending the service life of marine concrete infrastructure by mitigating water-driven deterioration. However, the widespread adoption in marine settings is hampered by inadequate chemical robustness, environmental concerns, and complicated...
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IQ-domain GTPase-activating protein 1 promotes the malignant phenotype of invasive ductal breast carcinoma via canonical Wnt pathway
Published 2017-05-01Get full textIQ-domain GTPase-activating protein 1 is a scaffolding protein with multidomain which plays a role in modulating dishevelled (Dvl) nuclear translocation in canonical Wnt pathway. However, the biological function and mechanism of IQ-domain GTPase-activating protein 1 in invasive ductal carcinoma (IDC...
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Peripheral Blood Exosomal miR-184-3p in Methamphetamine Use Disorder: Biomarker Potential and CRTC1-Mediated Neuroadaptation
Published 2025-06-01Get full textThe neurobiological mechanisms underlying methamphetamine use disorder (MUD) remain elusive, and specific treatment modalities as well as diagnostic markers are scarce. The emergence of exosomes has opened up possibilities for developing diagnostic and assessment biomarkers for neuropsychiatric diso...
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Transdiagnostic neuromodulation of impulsivity: current status and future trajectories
Published 2025-06-01Get full textAbstract Impulsivity, increasingly perceived as a transdiagnostic characteristic, significantly influences diverse psychiatric conditions and emanates beyond the boundaries defined by traditional classification systems. Transdiagnostic research has shed light on the complex clinical manifestations o...
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Metagenomic Analysis of Tick-Borne Viruses in Hulunbuir, Inner Mongolia, China: Epidemiological Risk of Potential Novel Pathogenic Viruses Relevant to Public Health
Published 2025-02-01Get full textInner Mongolia, with its vast grasslands providing ideal habitats for ticks, has recently emerged as a hotspot of novel tick-borne virus (TBV) prevalence. However, the diversity of TBVs and their potential spillover risks remain to be elucidated. In 2021, we collected 500 Haemaphysalis longicornis...
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