Search Results - Jiajun Li

Ovarian cancer (OC) is a common gynecological malignancy, and poly (ADP-ribose) polymerase inhibitor (PARPi) maintenance therapy has significantly prolonged the survival of newly diagnosed or platinum-sensitive recurrent ovarian cancer patients, which has become a new treatment paradigm for ovarian...

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Adeno-associated virus (AAV) vectors have emerged as the leading platform for retinal gene therapy due to their favorable safety profile, low immunogenicity, and ability to mediate long-term transgene expression within the immune-privileged ocular environment. By integrating diverse strategies such...

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Male infertility is a growing global health concern increasingly linked to environmental exposure to endocrine-disrupting chemicals (EDCs). However, the specific molecular mechanisms by which EDCs contribute to impaired reproductive function remain unclear. In this study, we systematically identifie...

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This study investigates an extreme squall line event that occurred in northern Jiangxi Province, China on 30–31 March 2024. Based on the WRF model, convection-permitting ensemble forecast experiments were conducted using two distinct initial perturbation approaches, namely, the Local Breeding of Gro...

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Grid-forming converters (GFMs) can enable power electronics to mimic the inertia response of synchronous generators (SGs), which can enhance the frequency stability of the ac grids with high penetration of renewable energy sources (RESs). However, GFMs potentially induce oscillations during frequenc...

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Female infertility, a global health concern affecting up to 12 % of women, is influenced by genetic, hormonal, and environmental factors. Among environmental contributors, endocrine-disrupting chemicals (EDCs), which interfere with hormonal systems, have gained attention for their potential impact o...

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Nerve regeneration after peripheral nerve injury (PNI) depends on exogenous and endogenous pro-healing signals in the microenvironment. Maintaining immune system homeostasis and remodeling the regenerative microenvironment are crucial prerequisites for promoting nerve regeneration. Here, a double-la...

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Antibody humanization is critical to reduce immunogenicity and enhance efficacy in the preclinical phase of the development of therapeutic antibodies originated from animal models. Computational suggestions have long been desired, but available tools focused on immunogenicity calculation of whole an...

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Clarifying evapotranspiration (ET) and its partition within ecosystems can provide a basis for understanding the interaction between the atmosphere and ecosystems. The Priestley-Taylor Jet Propulsion Laboratory (PT-JPL) model was used to carry out long-term simulation of ET and transpiration/evapotr...

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BackgroundBloodstream infection (BSI) exhibits elevated mortality, particularly among elderly patients manifesting atypical symptoms. Although blood culture (BC) remains the diagnostic gold standard, its limited sensitivity and prolonged turnaround time impede early detection. Droplet digital polyme...

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Introduction Aging is an irreversible biological process significantly influenced by oxidative stress, which smoking exacerbates. While the impact of direct smoking on aging is well-documented, the association between secondhand smoke (SHS) exposure and biological aging remains less explored. This s...

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