Search Results - Jiahong Chen

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  1. 1
    Theaflavins, theaflavin-3,3′-digallate, and its nanoparticles attenuate chronic alcohol-induced gastric injury and hepatic fibrosis by activating the AMPK/mTOR/Beclin1/LC3 autophagy pathway and modulating intestinal microbiota in ICR mice

    Theaflavins, theaflavin-3,3′-digallate, and its nanoparticles attenuate chronic alcohol-induced gastric injury and hepatic fibrosis by activating the AMPK/mTOR/Beclin1/LC3 autophag... by Ying Wang, Dan Zhang, Jiahong Chen, Ziyu Kong, Ling Wu, Zenghui Liu, Qingqing Zhai, Yan Xu

    Published 2025-08-01

    This study investigated the protective effects of theaflavins (TFs), theaflavin-3,3′-digallate (TFDG), and TFDG nanoparticles (TFDGN) against chronic alcohol-induced gastric and hepatic injuries in mice. Using an eight-week alcohol administration model, this study demonstrated that TFs, TFDG, and TF...

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  2. 2
    Cell division cycle 20 promotes tumor progression and predicts poor clinical outcome in childhood and adult adrenocortical carcinoma

    Cell division cycle 20 promotes tumor progression and predicts poor clinical outcome in childhood and adult adrenocortical carcinoma by Jiahong Chen, Peisheng Huang, Yongcheng Shi, Shanshan Mo, Cheng-Ya Hsu, Shumin Fang, Chuanfan Zhong, Le Zhang, Lanting Zuo, Jianming Lu, Weide Zhong, Zhuoya Huang, Zhong Dong

    Published 2025-09-01

    Background: Adrenocortical carcinoma (ACC) is an uncommon and highly aggressive tumor with a grim prognosis. Numerous investigations have elucidated a close association between the dysregulated expression of multiple genes within tumors and the initiation as well as progression of neoplasms. These d...

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  3. 3
    A novel organoid model retaining the glioma microenvironment for personalized drug screening and therapeutic evaluation

    A novel organoid model retaining the glioma microenvironment for personalized drug screening and therapeutic evaluation by Chengjun Zheng, Peng Wang, Delong Zhang, Zheng Fang, Yutong Feng, Jie Chen, Jiahong Chen, Yiwen Fu, Bao Yang, Shuqing Yu, Li Min, Bo Xiao, Cencan Xing, Yang Yang, Jianfeng Wang, Donghua Zou, Shipeng Ning, Tong Liu, Jun Yan, Qian Zhao, Fei Sun, Qiaodong Chen, Ying Zhang, Tao Jiang, Lemin Zheng, Zhaoshi Bao

    Published 2025-11-01

    Glioma is an aggressive brain tumor with a poor prognosis. Establishing an in vitro culture model that closely replicates the cellular composition and microenvironment of the original tumor has been challenging, limiting its clinical applications. Here, we present a novel approach to generate glioma...

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