Search Results - Jia-Wen Wang

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  1. 1
    The regulatory effects of PD-1/PD-L1 inhibitors on bone metabolism: opportunities and challenges in osteoporosis management

    The regulatory effects of PD-1/PD-L1 inhibitors on bone metabolism: opportunities and challenges in osteoporosis management by Jia-Wen Wang, Mu-Wei Dai, Jia-Hui Liu

    Published 2025-07-01

    Programmed death-1 (PD-1) and its ligand PD-L1 inhibitors have become pivotal agents in cancer immunotherapy, demonstrating significant efficacy across multiple malignancies. However, beyond regulating T cell activation, the PD-1/PD-L1 axis also exerts complex and critical effects on bone metabolism...

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  2. 2
    CTLA-4 and PD-1 combined blockade therapy for malignant melanoma brain metastases: mechanisms, challenges, and prospects

    CTLA-4 and PD-1 combined blockade therapy for malignant melanoma brain metastases: mechanisms, challenges, and prospects by Jia-Wen Wang, Ying-Fa Feng, Jia-Hui Liu

    Published 2025-07-01

    Malignant melanoma brain metastases (MBM) represent one of the deadliest complications of melanoma, with an incidence rate of 7.3%. Among patients with acral and mucosal melanoma, the cumulative 5-year incidence can reach 19.5%, accompanied by poor prognosis. The blood-brain barrier (BBB), an immuno...

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  3. 3
    Study critique and management strategies for femoral head osteonecrosis

    Study critique and management strategies for femoral head osteonecrosis by Duo Lu, Ke Zhang, Xiong-Wei Bai, Jia-Wen Wang

    Published 2025-07-01 Get full text
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