Αποτελέσματα αναζήτησης - Jeremy E. Orr
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Obstructive sleep apnea severity and pathophysiological traits in overlap syndrome: Insights from the SNOOzzzE cohort
Έκδοση 2025-07-01Λήψη πλήρους κειμένουAbstract The overlap syndrome (OVS), defined as coexisting chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA), is linked to worse outcomes than either condition alone. Patients with COPD and OSA may have fewer obstructive events, but underlying mechanisms remain unclear....
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Adaptive PRKAA1 variant in Andeans is associated with improved ventilation and sleep phenotypes
Έκδοση 2025-08-01Λήψη πλήρους κειμένουSummary: Highland groups have adapted to the extreme selective pressures of hypoxia at high altitude via alterations in the oxygen-transport cascade. PRKAA1, which encodes the catalytic subunit of the AMP-activated protein kinase (AMPK), is a notable target of natural selection in Andeans and has be...
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