Hakutulokset - Ivaylo Ivanov

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    Engineering a cell-based orthogonal ubiquitin transfer cascade for profiling the substrates of RBR E3 Parkin

    Engineering a cell-based orthogonal ubiquitin transfer cascade for profiling the substrates of RBR E3 Parkin Tekijä Shuai Fang, Li Zhou, Geng Chen, Jing Zhang, Xiaoyu Wang, In Ho Jeong, Savannah E. Jacobs, Bradley R. Kossmann, Wei Wei, Shu Liu, Geon H. Jeong, Yayun Xie, Duc Duong, Nicholas T. Seyfried, Ivaylo Ivanov, Angela M. Mabb, Hiroaki Kiyokawa, Bo Zhao, Jun Yin

    Julkaistu 2025-07-01

    Summary: The E3 ubiquitin (UB) ligase Parkin utilizes a Ring-Between-Ring (RBR) domain to mediate UB transfer to substrate proteins, and mutations affecting Parkin catalysis promote cancer and are associated with Parkinson’s disease. An essential role of Parkin is to initiate mitophagy by ubiquitina...

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