खोज परिणाम - Investigators

BACKGROUND Respiratory syncytial virus (RSV) is a major cause of morbidity in older adults. AIM We aimed to investigate the epidemiology of RSV in adults in five European countries and one region before and during the COVID-19 era. METHODS We conducted a retrospective analysis using national hospita...

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Abstract Aims Cardiogenic shock (CS) is a heterogeneous syndrome in which recent guidelines have proposed clinical phenotyping based on the presence of hypoperfusion and/or congestion signs and symptoms. However, the impact of this clinical phenotype on outcomes remains poorly characterized. Methods...

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Objective Quadriceps weakness increases the risk of knee osteoarthritis (OA) and functional decline. Understanding how quadriceps strength changes over time is crucial for managing knee OA. Knee pain and effusion may influence strength over time through inhibition of motor pathways, but this remains...

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ABSTRACT Objectives To compare the discrimination and calibration of six risk scoring systems in the assessment of patients with stroke‐associated pneumonia (SAP) after acute ischemic stroke. Methods The validation cohort was derived from the Third China National Stroke Registry. SAP was diagnosed a...

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<h4>Background</h4>There is currently no validated risk prediction model for recurrent events among patients with acute ischemic stroke (AIS) and atrial fibrillation (AF). Considering that the application of conventional risk scores has contextual limitations, new strategies are needed t...

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Aims: Performance indicators are increasingly used to evaluate the quality of healthcare provided to patients following a hip fracture. In this systematic review, we investigated the association between ‘early mobilization’ after surgery and patient outcomes. Methods: Evidence was searched through 1...

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<h4>Background</h4>Outcome selection is a critically important aspect of clinical trial design. Alive-and-ventilator free days is an outcome measure commonly used in critical care clinical trials, but has not been fully explored in resuscitation science.<h4>Methods</h4>A simu...

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<b>Background/Objectives</b>: The increased use of antibiotics is raising concerns about environmental contamination and antibiotic resistance, exemplified by the case of cotrimoxazole, a widely prescribed combination of sulfamethoxazole and trimethoprim. After oral administration and ab...

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<h4>Purpose</h4>To investigate if the timing of initiation of invasive mechanical ventilation (IMV) for critically ill patients with COVID-19 is associated with mortality.<h4>Materials and methods</h4>The data for this study were derived from a multicenter cohort study of cri...

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The aim of this study is to ascertain whether qRT-PCR (reverse transcriptase real-time PCR) or RT-ddPCR (reverse transcriptase digital droplet PCR) is more effective for detecting SARS-CoV-2 RNA (severe acute respiratory syndrome coronavirus 2 RNA) in blood plasma from COVID-19 (coronavirus infectio...

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ABSTRACT Introduction Systemic opioids are recommended as a pharmacological treatment for dyspnea, and antipsychotics are widely used for delirium. Because little is known about optimal palliative pharmacological strategies for dyspnea in patients with delirium, this study explored the symptom cours...

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Beta-blockers have been considered the cornerstone of treatment for patients with acute myocardial infarction (AMI). However, long-term benefits of vasodilating beta-blockers remain uncertain. This study aimed to investigate the long-term clinical benefits of vasodilating beta-blockers compared to c...

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<h4>Background and aims</h4>Predicting progression and prognosis in Interstitial Lung Diseases (ILD), especially Idiopathic Pulmonary Fibrosis (IPF) and Progressive Pulmonary Fibrosis (PPF), remains a challenge. Integrating patient-centered measurements is essential for earlier and safer...

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Abstract Aims The PANORAMA‐HF trial demonstrated significant N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) reductions in paediatric patients with left ventricular systolic dysfunction with sacubitril/valsartan or enalapril treatment over 52 weeks. This post hoc analysis aims to correlate cha...

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<h4>Background</h4>Adults with chronic kidney disease (CKD) are hospitalized more frequently than those without CKD, but the magnitude of this excess morbidity and the factors associated with hospitalizations are not well known.<h4>Methods and findings</h4>Data from 3,939 par...

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Canada's opioid crisis continues to escalate. Naloxone can effectively reverse the effects of opioid overdose. We planned a randomized trial on the effectiveness of a point-of-care overdose education and naloxone distribution (OEND) intervention on participants' performance in a simulated...

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Background: Mucosal immunity plays a pivotal role in preventing infections with SARS-CoV-2. While COVID-19 mRNA vaccines induce robust systemic immune responses in patients with inflammatory bowel disease (IBD), little is known about their efficacy in the mucosal immune compartment. In this sub-inve...

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Abstract Aims We aimed to assess the impact of pre‐admission beta‐blocker (BB) therapy on the clinical characteristics, in‐hospital treatment and outcomes of patients with cardiogenic shock (CS). Methods All patients enrolled in the multicentre prospective Altshock‐2 registry since March 2020 with a...

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