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    SENP1-Sirt3 axis regulates type II alveolar epithelial cell activity to confer resistance against oxidative damage in lung tissue

    SENP1-Sirt3 axis regulates type II alveolar epithelial cell activity to confer resistance against oxidative damage in lung tissue mā Mingming Zhang, Xin Lin, Jianli He, Yong Zuo, Qiuju Fan, Innocent Agida, Hongsheng Tan, Caiying Zhu, Jinke Cheng, Tianshi Wang

    I whakaputaina 2025-09-01

    Oxidative damage exacerbates pulmonary fibrosis by impairing alveolar type II epithelial (AT2) cell function. This study demonstrates that the SUMO-specific protease 1 (SENP1)-Sirtuin 3 (Sirt3) axis, critical for mitochondrial redox regulation, is suppressed in AT2 cells during lung injury. In bleom...

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