खोज परिणाम - I. Yu. Torshin

Background. Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) are widely used in modern cardiology. The anti-inflammatory effect of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is realized, in particular, by modulating the activity of the arachidonic acid (ARA) cascade.Objective: to cond...

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Maintaining adequate levels of nitric oxide (NO) in the blood and other body tissues is necessary for the regulation of vascular tone, blood pressure, maintenance of oxygen metabolism and endothelial function. NO is also involved in regulating the balance of excitatory (glutamate) and inhibitory (ga...

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Purpose of the study. The pharmacological effects of ornithine are primarily due to its participation in the neutralization of ammonia and in the metabolism of amino acids. To clarify the mechanisms of action of ornithine, a chemoreactom analysis of ornithine aspartate was performed in comparison wi...

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Background. Therapy of hyperlipidemia with synthetic statin drugs is characterized by a number of side effects. In particular, statin-dependent myopathy occurs as a result of statin inhibition of biosynthesis of cofactor coenzyme Q10 (CoQ10), which plays a central role in the electron transport chai...

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Orotic acid is one of the intermediates in the pyrimidine biosynthesis. Mechanisms of physiological effects of orotic acid are poorly known. Analysis of data about these mechanisms is presented. Effects of orotic acid and magnesium orotate on cardiovascular system as well as therapeutic implementati...

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Objective: comprehensive analysis of the spectrum of antibacterial action of bactеriocins.Material and methods. Chemomicrobiome analysis of bacteriocins A/B, C, S, 28b, RS-2020 was performed to assess the minimum inhibitory concentration (MIC) values for 152 strains of pathogenic bacteria and the ar...

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Objective: to conduct chemoreactomic, pharmacoinformatic and chemoneurocytological analyzes of the properties of racetams (piracetam, aniracetam, pramiracetam, levetiracetam, fonturacetam).Material and methods. Chemoreactomic, pharmacoinformatic and chemoneurocytological methods of molecule properti...

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Antibiotics are most often used to combat urinary tract infections (UTIs). Taking into account the side effects related to antibiotic therapy, existing antibiotic-resistant strains of uropathogens, as well as the low effectiveness of the vast majority of antibiotics against bacterial agglomerations...

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Background. Phenol and parabens exert bactericidal properties, are relatively low-toxic (in acute toxicity tests) and are used in pharmaceutical, cosmetic and food industries as stabilizers/preservatives for the final product. Despite their widespread use, the long-term toxicological effects of phen...

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Background. Antibiotics have different spectra of action on bacterial pathogens, including their antibiotic-resistant strains. Establishing the spectra of action of antibiotics and mechanisms of resistance to them is an important task for finding effective and safe antibiotic therapy.Objective: a ch...

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Mass spectrometric sequencing of peptides in Laennec indicated the presence of 5 peptides in the drug, the biological activity of which may determine the antibacterial properties of the drug. The most significant result of this study is the presence in Laennec of a fragment of the antibacterial pept...

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The article presents an analysis of publications on myoinositol in order to clarify the possibilities of prescribing drugs based on it. Myoinositol is one of the endogenous human metabolites that has a significant effect on the functioning of cells and tissues of the whole body. The main function of...

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Currently, the study of promising “biogenic stimulants” that exhibit pathogenetic effects in relation to various diseases continues. The first results of studies of peptide “biogenic stimulants” based on human placenta extracts (HPE) were obtained by Prof. Filatov VP in the thirties of the 20th cent...

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Background. Neurotransmitter adenosine and B-group vitamins have neuroprotective, remyelinizing and anti-neuroinflammatory properties. Despite the studies of these molecules for decades, the molecular mechanisms of their synergistic effect on neuroinflammation processes are unexplored and not system...

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Chondroitin sulfate (CS) and glucosamine sulfate (GS) are used in the treatment of osteoarthritis and exhibit a pronounced anti-inflammatory effect. CS/GS inhibit the NF-kB signaling cascade, which realizes the biological effects of tumor necrosis factor (TNFa). Excessive activity of NF-kB also stim...

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Systems biology analysis of over 700 magnesium-dependent proteins in human proteome shown that these proteins affect (1) the embryonic development, (2) energy metabolism, (3) signal transduction processes from receptors, (4) neurological function, (5) support of connective tissue structure, (6) card...

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Aluminium magnesium hydroxide sulfate 5:10:31:2 (magaldrate) is used as an antiacid which neutralizes excess of hydrochloric acid in the stomach. In joint application with siloxane polymer of simethicon, magaldrate shows minimum of side effects (in particular, does not cause high gassing) against th...

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Background. The complex mechanisms of action of chondroitin sulfate (CS) and glucosamine sulfate (GS) at the molecular level make it possible to assert the applicability of the corresponding drugs far beyond chondroprotection. Inhibition of proinflammatory mechanisms (NF-κB, activation of toll-recep...

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Background. Nitric monooxide (NO) is a signaling molecule that plays an important role in many physiological processes, including the regulation of vascular tone, neurotransmission, immunity, mitochondrial respiration, and skeletal muscle contractility. Certain molecules, which are micronutrients or...

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