Hakutulokset - I. V. Smirnov
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1
Mutation hot spots in MICA/MICB extracellular domains
Julkaistu 2023-06-01Hae kokotekstiMICA and MICB are non-classical MHC molecules that indicate cellular stress. They act as ligands for NKG2D receptors found on NK cells, thereby triggering a cytotoxic response against damaged, infected, or transformed cells. The production of soluble forms of MICA/MICB occurs via the cleavage of the...
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2
Determinants Factors in Predicting Life Expectancy Using Machine Learning
Julkaistu 2023-01-01Hae kokotekstiIntroduction. Life expectancy is, by definition, the average number of years a person can expect to live from birth to death. It is therefore the best indicator for assessing the health of human beings, but also a comprehensive index for assessing the level of economic development, education and he...
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3
Stress-induced MICA and MICB molecules in oncology
Julkaistu 2022-07-01Hae kokotekstiMICA and MICB molecules, MHC class I chain-related proteins, are expressed on the membranes of damaged, transformed or infected cells. These glycoproteins bind to the NKG2D receptor of NK cells, resulting in their activation and cytotoxic response against MICA- and/or MICB-expressing cells. Expressi...
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4
Comparison of machine learning models for coronavirus prediction
Julkaistu 2022-03-01Hae kokotekstiCoronavirus, also known as COVID-19, was first detected in Wuhan, China, in December 2019. It is a family of viruses ranging from the common cold to severe acute respiratory syndrome (SARS). The symptoms of such a virus are similar to those of a cold or seasonal allergies. Like other respiratory vir...
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5
Antioxydant and prooxydant effects of arbutin and hydrohinon in experiment in vitro
Julkaistu 2011-10-01Hae kokotekstiThe object of research is to compare antioxidant and prooxydant activity of arbutin and hydrochinon in vitro. Antioxidant and prooxydant activity of arbutin and hydrochinon is estimed of their ability to suppress/ induct oxydation ТВИН-80. Arbutin and hydrochinon have antioxydant and prooxydant prop...
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Complex Bronchofibroscopy in the Diagnosis of Pulmonary Complications in Intensive Care Unit Patients
Julkaistu 2013-02-01Hae kokotekstiObjective: to determine the efficiency of bronchofibroscopy (BFS) and cytology of bronchoalveolar lavage fluid (BALF) for the diagnosis of pulmonary complications in resuscitation patients with varying acute therapeutic and surgical diseases. Subjects and methods. Twenty-seven patients treated at th...
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7
IL-6 and IL-8 secretion by human glioma cells proliferating after Gamma-knife irradiation
Julkaistu 2023-06-01Hae kokotekstiOne of the modern methods of treating patients with primary and recurrent brain tumors is radiosurgical irradiation using Gamma Knife, which allows therapeutic doses to be delivered to tumors not exceeding 2.5 cm in diameter in 1–2 sessions. Tumor cells on the periphery of this tissue volume that re...
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8
<i>PD-L1</i> and <i>PD-L2</i> gene expression in human glioblastoma cells resistant to chemo- and radiotherapy
Julkaistu 2023-06-01Hae kokotekstiMembrane molecules PD-L1 and PD-L2, ligands of T lymphocytes PD1 receptor, perform immunoregulatory functions. Their binding to the receptor leads to inhibition of proliferation, reduction of cytokine production, cytotoxic response, and apoptosis of T lymphocytes. The cells of many tumors, regardles...
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Impact of Neuroaxial Block on Hemodynamic Changes in Puerperas
Julkaistu 2006-04-01Hae kokotekstiThe results of the multicentric study on «The safety of the spinal anesthesia during the caesarean section» describing the analysis of the hemodynamic changes due to neuroaxial block in parturients were presented. Thirteen clinics participated in the study. The volume of the sampling includes 2228 s...
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