Search Results - I. Panasenko
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Pharmacological potential of 3,5-dimethyl-4-(3-(5-nitrofuran-2-yl)allylidenamino)-1-alkyl-1,2,4-triazolium bromides
Published 2024-06-01Get full textThe discovery of new 1,2,4-triazole derivatives offers significant potential for the development of innovative medications. Researchers often favor derivatives of this heterocyclic system due to their ability to create chemical structures with desired pharmacokinetic and pharmacodynamic properties,...
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Research on the pharmacological potential of 1-alkyl derivatives of 3,5-dimethyl-4-((4-nitrobenzylidene)amino)-1,2,4-triazolium bromide
Published 2024-11-01Get full textand its derivatives is one of the leaders in the development of highly promising biologically active compounds. The peculiarities of the chemical structure of the derivatives of this heterocycle provide a wide range of possibilities for chemical transformations that allow to obtain really effective...
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Synthesis, antimicrobial and antifungal activity of 3-(2-bromophenyl)-5-(alkylthio)-4-phenyl-4H-1,2,4-triazoles
Published 2022-12-01Get full textTo select a molecule that could become a promising pharmacological agent, chemists use already-known heterocyclic bases by adding pharmacologically active groups. One such heterocyclic system is 1,2,4-triazole base, on the basis of which a huge number of biologically active compounds have already be...
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Search for antibacterial activity in a number of new S-derivatives (1,2,4-triazole-3(2H)-yl)methyl)thiopyrimidines
Published 2021-07-01Get full textThe relevance of the study of 1,2,4-triazole derivatives with pyrimidine fragment is due to the synthesis of potential broad-spectrum antibacterial drugs, low molecular weight inducers of interferon, and antitumor agents, search for molecular descriptors of their structure, important for establishin...
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Synthesis and properties of some 3-(5-(4-methoxyphenyl)pyrazol-3-yl)-6-R-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles
Published 2022-08-01Get full textPyrazole and 1,2,4-triazole derivatives play an important strategic role in modern medicine and pharmacy. This fact is due to the significant possibilities of chemical modification and significant pharmacological potential among the derivatives of these heterocycles. The introduction of 1,2,4-tria...
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Assessment of the role and participation of pharmacists in the provision of palliative care
Published 2025-07-01Get full textThe aim of the study was to investigate the position of pharmacists regarding their place and role in providing palliative care to patients with serious or terminal illnesses. Materials and methods. The data from a survey of pharmacists from various pharmacies conducted through an online survey i...
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Machine vision system with the possibility of automated 3d vir¬tual space construction with further implementation in it of capture and recording of changed registred points of cer...
Published 2022-06-01Get full textThe article describes in detail the step-by-step process of the development and operation of a machine vision system using modern approaches to software development and the subsequent creation and implementation of control of a robotic limb at a distance using microcontroller tools that implement hi...
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In silico evaluation of the pharmacodynamic component of the interaction of S-alkyl derivatives of 5-methyl-4-(p-tolyl)-1,2,4-triazole-3-thiol with some biological targets
Published 2023-11-01Get full textDerivatives of 1,2,4-triazole open wide opportunities for modern and progressive scientists in the development of innovative medicines. These compounds are known for their variability and structural flexibility, which allows scientists to experiment and create new molecules with unique properties. T...
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Discussion of antimicrobial and antifungal activity of 4-amino-5-methyl-4H-1,2,4-triazole-3-thiol
Published 2017-04-01Get full textStudying new biologically active substances nowadays become increasingly important. The current range of the pharmaceutical market requires constant updating of domestic products. The main requirements for new medications are high efficiency and low toxicity. Aim. Modern pharmaceutical science sepa...
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The acute toxicity of 5-thio-substituted 3-(5-bromofuran-2-yl)-4-ethyl-(4H)-1,2,4-triazole derivatives
Published 2015-08-01Get full textAim. Research of the acute toxicity of new compounds could prevent the development of compounds with high pharmacological activity, which exhibit undesirable pharmacological properties. Therefore, on the first stages of research the study of the acute toxicity of new compounds is quite actual. Me...
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Analgesic activity of 4-amino-5-methyl-4H-1,2,4-triazol-3-thiones
Published 2018-10-01Get full textАbstract Significance. Nowadays non-steroidal anti-inflammatory drugs have found a wide application in treatment of medical conditions. Despite the clinical effectiveness of non-steroidal anti-inflammatory drugs, their administration is followed by a set of side effects. With aim to reveal the su...
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Synthesis, physical-chemical properties of 2-((4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-yl)thio)acetohydrazides
Published 2017-04-01Get full textAim. Analysis of the scientific literature over the past decade has shown that large synthetic possibilities towards creating new and effective drug substances have heterocyclic compounds, in particular the derivatives of 1,2,4-triazole. 1,2,4-Triazole is a structural fragment of many synthetic drug...
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Synthesis of ylidene derivatives of 4-amino-5-(4-tert-butylphenyl)-4H-1,2,4-triazole-3-thiol
Published 2015-08-01Get full textAim. Modern medicine widely applies drugs from the group of 1,2,4-triazole (fluconazole, triazolam, alprazolam, letrozole and others) in the practice. This class of compounds has synthetic origin and a broad spectrum of biological activity, and is characterized by low toxicity. It is known that the...
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Synthesis, physical and chemical properties, antihypoxic activity of some 5-[((5-(adamantane-1-yl)-4-R-4H-1,2,4-triazole-3-yl)thio)methyl]-N-R1-1,3,4-thiadiazole-2-amines and 5-[((...
Published 2018-03-01Get full textToday, an increase of natural and technogenic situations leads to the disorders of the central nervous system, functional-metabolic processes, vascular diseases, in particular, acute cerebral blood flow disorders. In addition, the changes occurring on the molecular and cellular levels are in the bas...
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Acute toxicity of 2-(5-(adamantane-1-yl)-4R-1,2,4-triazole-3-ylthio) of the acetic acids and their salts’ derivatives
Published 2015-12-01Get full textAim. To study the acute toxicity of 2-(5-(adamantane-1-yl)-4R-1,2,4-triazole-3-ylthio) acetic acids and their salts’ derivatives. Methods and results. According to the data the acute toxicity of investigated substances belongs to the 4th class of toxicity and they are low-toxic, their LD50 ranges...
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Search for molecular descriptors and computer prediction of biological activity in a series of S-derivatives (1,2,4-triazole-3(2H)-yl)methyl)thiopyrimidines
Published 2024-02-01Get full textMost pharmaceutical compounds interact with various molecular compositions in the body, leading to complex biological effects. Furthermore, during biotransformation, they may generate one or more metabolites with potent bioactive properties. Therefore, the development and careful use of new medicati...
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Synthesis and properties of bis((4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)alkanes
Published 2018-08-01Get full textThe aim of this work was the synthesis of bis((4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)alkanes using available reagents and study of their properties. Matherial and methods. 4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-thiol was used as an intermediate compound, obtained from met...
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SYNTHESIS AND PHYSICAL-CHEMICAL PROPERTIESOF 3-ARIL-2-((3-(3-FLUORPHENYL)-1,2,4-TRIAZOLE-5-YL)THIO)PROP-2-EN-1-OLES
Published 2015-04-01Get full textModern scientific schools, which search for new biologically active substances of synthetic nature, pay special attention to synthetic heterocyclic systems with nitrogenatom. Among these heterocyclic compounds, the derivatives of 1,2,4-triazole should be mentioned. Many publications of both domesti...
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Synthesis and physical-chemical properties of 3-(4-(tert-butyl)phenyl)-5-(R-ylthio)-4H-1,2,4-triazol-4-amines
Published 2016-04-01Get full textAim. 1,2,4-triazole derivatives are widely used in medical practice due to its wide range of biological effect and small toxicity. This fact makes this class of organic heterocyclic compounds especially interesting and promising for the study of their physical-chemical and biological properties. Thi...
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Antihypoxic activity of benzylidenhydrazides of 4-R-5- (thiophene-2-ylmethyl)-1,2,4-triazol-3-il)thioacetic acid
Published 2017-08-01Get full textIn recent years we see significant increase of natural and technogenic situations that lead to disorders of functional and metabolic processes of central nervous system and cardiovascular diseases, including acute cerebrovascular accident. The leading factor in vascular brain pathology is hypoxia. C...
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