Search Results - I. A. Khlusov

Modulating influence of electric impulses, visible light, some microelements is studied in parameters which are near to physio-logic ones on life activity of progenitor and mature cells of blood system in vitro and in situ. Content of granulocyte and fibroblastoid colony-forming units, concentration...

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Purpose. In experiment in vivo to study the features of regeneration of the conjunctiva and sclera of rats after surgery with intraoperative application of a 0.05% Ciclosporin A.Materials and methods. Еxperimental animals (rats) (n = 48) were divided into the main group, including the subgroups a (n...

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The review is devoted to the methods of bioimmunotherapy of oncological pathology used in the clinic for the recent 20—25 years and, to the higher extent, the principles of cellular immunotherapy of cancerous epithelial tumors of the digestive system. The surgical method is recognized as a «gold sta...

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Background. The diffusion chamber method helps solve the problem of delivering a biomaterial with minimal losses, while creating an isolated environment in the recipient’s body. The issue of vascularization of diffusion chambers to preserve the functional capacity of the biomaterial remains relevant...

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Aim. In an in vivo experiment, to study the effect of local intraoperative application of 0.05% cyclosporin A solution on the conjunctival and scleral regeneration after surgery on the rabbit eyes with steroid-induced  glaucoma.Materials and methods. At the first stage of the experiment, a model of...

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Aim. To study platelet adhesion to a-C:H:SiOx film on titanium in an in vitro experiment to evaluate its antithrombogenic potential.Materials and methods. Thin (less than 1 μm) a-C:H:SiOx films were deposited on VT-6 titanium plates with a size of 10 × 10 mm2 and a thickness of 0.2 mm using a vacuum...

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Introduction. The development and implementation of new effective and safe drugs with osteogenic activity is an urgent problem of modern medical and pharmaceutical sciences. This is due to the wide prevalence and complexity of the treatment of diseases of the musculoskeletal system, which entails si...

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Activities of total alkaline phosphatase (TALP) and its bone isoform (BALP) was greater in groups of children and adolescents in the late posttraumatic period (pattern of reparative bone remodeling) and scoliosis (pathological bone remodeling), than in the control (healthy children and adolescents)....

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The purpose of this study is to estimate Ex vivo physicochemical and biological features of three-dimensional (3D) biodegradable matrices “polylactic acid/calcium phosphates” (hereafter 3D composites) designed with the help of additive technologies (3D printing) as potential materials for bone tissu...

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In the modern world, oncological diseases occupy the leading positions in the structure of mortality. An integrated approach to oncotherapy is not only aimed at immediate affection of malignant tumors, but also directed at reducing the risk of tumor recurrence and metastasis, as well as alleviating...

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The aim of the research is to study the possibility of using track-etched membrane, including track-etched membranes modified with cold plasma, followed by layering prenatal stem cells (PSC) on the material surface in surgical treatment of bullous keratopathy (BK). Materials and methods. The track m...

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Aim. This research studies the effect of a low-temperature atmospheric plasma and the subsequent γ-ray sterilization on topography and properties of track membranes (TM) based on polyethylene terephthalate (PET).Materials and methods. TM were obtained by irradiating a PET film with a 40Ar+8 ion beam...

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Aim: to review current scientific literature concerning the main advances and problems of magnesium (Mg) alloys for traumatology and orthopedics. Methodology of the study. Analytical review based the comprehensive investigation of public scientific and technological sources. Results of the study. Mo...

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One of the promising areas is the design and modification of materials for control over the fate of multipotent mesenchymal stromal cells (MMSCs) that will allow stroma of various human and animal organs and tissues to be constructed. However, the discussion about the existence and functioning of mi...

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The purpose of the study is to evaluate the cellular and molecular parameters of bone remodeling in the blood as potential markers of undifferentiated forms of connective tissue dysplasiaMaterials and methods. The structural and functional status of cellular elements of in vitro culturing of mononuc...

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The use of intramedullary bioactive osteosynthesis combined with Ilizarov’s apparatus is promoting to correction of skeletal deformations and is allowing putting patients with osteogenesis imperfecta on their legs. Morphofunctional parameters of blood mononuclear cells can be considered as probable...

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Drug development & registration. 2024;13(4):45–59. (In Russ.) https://doi.org/10.33380/2305-2066-2024-13-4-1897. Published: 15.11.2024.

The culture of stromal stem cells was incubated under constant and dynamic conditions. The incubation period was lasting 48 h. Intracellular enzyme activity of stromal stem cells were carried out with cytochemical methods. Alkaline phosphatase activity was increased under dynamic conditions, differe...

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Aim. To analyze the structural, magnetic, and cytotoxic features of magnetite nanoparticles (MNPs) prepared by the exploding wire method and stored in a dark place at ambient temperature (65 ± 15% humidity, air pressure 760± 20 mm Hg., temperature 22 ± 4 °C) for 10 years.Materials and methods. The p...

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The aim is to study the basic physico-mechanical properties of hydroxyapatite (HA) composites (up to 25–50 wt%) with polylactide (PLA-HA) and poly(e-caprolactone) (PCL-HA) prepared by melt compounding, as well as the osteogenic potential of PLA-HA in vivo.Materials and methods. All biodegradable pol...

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