Search Results - I. A. Goncharova
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GENETIC FACTORS INFLUENCING THE EFFECTIVENESS AND SAFETY OF LONG-TERM ANTICOAGULANT THERAPY
Published 2013-06-01Get full textLate postoperative thrombotic and haemorrhagic complications in anticoagulant-treated patients remain one of the key problems of the modern clinical medicine. At present, the most widely used anticoagulant is warfarin, a vitamin K antagonist. One of the reasons for a pathological reaction to the the...
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Structure of comorbidity in ascending aortic aneurysm
Published 2023-01-01Get full textAim. To analyze the comorbidity structure in patients with ascending thoracic aortic aneurysm (TAA) in the Siberian Federal District (SFD).Material and methods. The study included 163 patients (114 men (56,8±12,1 years) and 49 women (59,4±10,4 years)) with ascending TAA, who underwent open surgical...
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Changes in DNA methylation profile in liver tissue during progression of HCV-induced fibrosis to hepatocellular carcinoma
Published 2023-03-01Get full textIn this study we compared methylation levels of 27,578 CpG sites between paired samples of the tumor and surrounding liver tissues with various degrees of damage (fibrosis, cirrhosis) in HCV-induced hepatocellular carcinoma (HCC) patients, as well as between tumor and normal tissue in non-viral HCC...
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Putative regulatory functions of SNPs associated with bronchial asthma, arterial hypertension and their comorbid phenotype
Published 2022-01-01Get full textLinkage disequilibrium (LD) of single nucleotide polymorphisms (SNPs) of TLR4/AL160272.2 (rs1927914, rs1928298, rs7038716, rs7026297, rs7025144) was estimated in the Slavs of West Siberia. We further investigated an association of SNPs in TLR4/AL160272.2 (rs1927914, rs7038716, rs7025144), SERPINA1 (...
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ROLE OF THE VARIABLE SITES G-1082A AND C-592A OF GENE IL10 IN DEVELOPMENT OF ONE YEAR ADVERSE OUTCOMES OF ST ELEVATION ACUTE CORONARY SYNDROME
Published 2017-11-01Get full textAim. Evaluation of the association of variation sites G-1082A (rs3024491) and C-592A (rs1800872) gene IL10 with one year outcomes of ST elevation acute coronary syndrome (STEACS).Material and methods. Totally, 178 patients included, with STEACS in whom the polymorphisms C-592А (rs1800872) and G-1082...
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Analysis of association of polymorphic variants of genes GSTP1 and GSTM1 with survival rate sick of liver cirrhosis of a virus and alcoholic etiology
Published 2009-04-01Get full textWith the purpose of studying of association of polymorphic variants of genes glutathione S-transferases pi and mu (GSTP1 and GSTM1) with survival rate sick of liver cirrhosis (LC), it is lead uniinstantly research of 189 sick of LC of a virus (HBV, HCV, H V+H V) and an alcoholic etiology. Have been...
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POTENTIAL OF PHARMACOGENETICS IN THE CORRECTION OF ANTICOAGULANT THERAPY AMONG PATIENT WITH PROSTHETIC HEART VALVES
Published 2013-06-01Get full textAim. To compare the effectiveness of various pharmacogenetics algorithms of warfarin dosage and to identify the strengths and limitations of standard genetic tests for the warfarin dose correction during the late postoperative period among 134 warfarin-treated patients with prosthetic heart valves.M...
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Analysis of haplotypes of CAT, TLR4, and IL10 genes in bronchial asthma patients comorbid with arterial hypertension
Published 2020-01-01Get full textCo-occurrence of cardiovascular diseases is significantly common among patients with bronchial asthma. Genetic factors can have a significant effect on the development of hypertension in patients with asthma. Objective of the study was to investigate the associations of polymorphic variants relating...
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ASSOCIATION OF A LYMPHOTOXIN-α VARIABLE SITE rs1041981 WITH DEVELOPMENT OF LONG-TERM UNFAVORABLE OUTCOMES IN PATIENTS WITH ACUTE CORONARY SYNDROME WITHOUT ST-SEGMENT ELEVATION
Published 2018-01-01Get full textLymphotoxin-α (LTA) is a major pro-inflammatory cytokine produced at the early stages of vascular inflammation, taking part in the formation of arterial atherosclerosis and development of coronary heart disease. Functional changes in the gene encoding LTA production may influence the development of...
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Liver injury under chronic viral hepatitis C against the background of opiomania: morphological characters
Published 2011-02-01Get full textTo ascertain the severity of opium-induced liver injury for chronic viral hepatitis C (HCV) patients with detection of morphological characters of hepatocyte impact by opiates.Needle biopsy of liver and the light microscopy of biopsy material were made both for isolated HCV and HCV+opiomania patient...
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THE STUDY OF RS1800629 (G-308А) POLYMORPHISM OF THE TNF GENE IN PATIENTS WITH MYOCARDIAL INFARCTION WITH ELEVATED ST SEGMENT
Published 2014-10-01Get full textAim. To study the clinical and predictive importance of polymorphism of rs1800629 (G-308A) of TNF gene in patients with STEMI.Material and methods. Research included patients (171 persons with STEMI), hospitalized to the Kemerovo cardiological center and 188 individuals without the diagnosed cardiov...
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Deoxyribonucleic acid methylation in the enhancer region of the CDKN2A/2B and CDKN2B-AS1 genes in blood vessels and cells in patients with carotid atherosclerosis
Published 2020-11-01Get full textAim. Comparative analysis of the deoxyribonucleic acid (DNA) methylation level in the enhancer region of the CDKN2A/2B and CDKN2B-AS1 genes (9p21.3 locus) in vessels with/without atherosclerotic lesions, as well as in leukocytes of patients with clinically relevant carotid artery (CA) atherosclerosi...
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