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    SENP3 protects hepatocyte from pyroptosis during acute liver injury through deSUMOylation of HNRNPL

    SENP3 protects hepatocyte from pyroptosis during acute liver injury through deSUMOylation of HNRNPL by Xinyuan Xiong, Yang Zhi, Nan Yang, Wenzhen Zhao, Shu Wang, Huiqin Zhu, Jieting Tang, Jing Yi, Xuxu Sun, Jie Yang

    Published 2025-08-01

    Summary: Protein SUMOylation is crucial in both physiological and pathological contexts, but its role in acute liver injury (ALI) is poorly understood. We found that SENP3, a SUMO2/3 protease, rapidly accumulates in hepatocytes around the pericentral vein zone within 2 h of carbon tetrachloride (CCl...

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