Search Results - Hui Shen

Colorectal cancer (CRC) is the second most common cause of cancer-related mortality worldwide and one of the most frequently diagnosed malignancies. Conventional CRC screening techniques—such as colonoscopy and pathologic biopsy—are invasive procedures that often cause patient discomfort and carry r...

Full description

Sea surface temperature (SST) fronts during 2000–2021 are examined in the Western Gulf of St. Lawrence (wGSL), where North Atlantic right whales (NARW, <i>Eubalaena glacialis</i>) have begun to aggregate and feed. During 2017–2020, from May to October, NARW spatial distributions reveal r...

Full description

In this paper, we present a fluorescence collection enhancement method for multiphoton microscopy by a quarter ellipsoidal reflector (QER). It is proven to be compatible with commercially available two-photon microscopes without significant customization. The structure and working principle of the Q...

Full description

BackgroundAnkylosing spondylitis (AS) is an autoimmune disease characterized by bone destruction and abnormal remodeling. Metrnl, a secreted protein involved in inflammation and immune regulation, has recently been linked to bone growth. This study aimed to evaluate serum Metrnl levels in AS patient...

Full description

The influence of Tm-doped pedestal fiber splice on the output performance of a large-mode-area (LMA) Tm-doped fiber laser (TDFL) has been investigated. Arc-fusion induced refractive-index deformation leads to laser leakage from the core to the pedestal, resulting in a periodic decrease in the output...

Full description

None

The interaction between keratinocytes (KCs) and immune cells is essential in the pathogenesis of psoriasis. Understanding this crosstalk is crucial for developing effective treatment strategies. Recent studies indicate that Rh family C-type glycoprotein (RHCG) enhances cell proliferation and alters...

Full description

As a model system for studying the structure–property relationship and surface coordination chemistry of metal nanomaterials, ligand-stabilized, atomically precise coinage–metal (Au, Ag, and Cu) nanoclusters (NCs) have attracted considerable attention. Extensive effort has been devoted to the synthe...

Full description

Colorectal cancer pathogenesis is a multifactorial process, with genetic factors playing a significant role in cancer development. A review of published meta-analyses on MTHFR gene polymorphisms and colorectal cancer susceptibility showed inconsistent findings and failed to assess the reliability of...

Full description

Background: Aquablation (AquaBeam, PROCEPT BioRobotics, CA, USA), which utilizes machine-controlled water jets to ablate the prostate tissue, is a new technology that was approved for urologic surgery in Taiwan in May 2022. Objectives: This study aimed to explore the initial surgical outcomes of aqu...

Full description

Fruit yield is the most important horticultural trait of tomato. SlMBP21, a SEPALLATA subclass MADS-box gene has been reported to have functions in regulating pedicel abscission zone identity and development and controlling sepal size in tomato. However, we generated transgenic tomato plants which o...

Full description

This study explores the therapeutic potential of the cooling blood and detoxicating formula (CBDF) in the treatment of psoriasis, emphasizing its anti-inflammatory properties and its interaction with RHCG-related mechanisms. Psoriasis, a complex skin disorder characterized by abnormal keratinocyte p...

Full description

Classical swine fever caused by Classical swine fever virus (CSFV) is a serious problem for swine industries in developing countries, which successful control of the disease have been relying on vaccination. However, classical swine fever still occurs in some immunized swine herds for various reason...

Full description

Background Tumor cells manipulate the tumor-associated antigens presentation to escape immune surveillance; however, the molecular mechanism is not exactly clear and the measure to intervene is missing.Methods Annexin A2 was knockout by the CRISPR-Cas9 or blocked by the small-molecule matrine, PY60,...

Full description

Background: No robust biomarkers have been identified to predict the efficacy of programmed cell death protein 1 (PD-1) inhibitors in patients with locoregionally advanced nasopharyngeal carcinoma (LANPC). We aimed to develop radiomic models using pre-immunotherapy MRI to predict the response to PD-...

Full description

We designed and developed a novel DNA topoisomerase I inhibitor MF-6, which was a more potent cytotoxin and a more potent inducer of immunogenic cell death compared with DXd. To utilize MF-6’s ability to induce antitumor immunity, a human epidermal growth factor receptor 2 (HER2)-targeted antibody–d...

Full description

Summary: Background: Conventional diagnostic tools, including ultrasound, fine-needle aspiration cytology, and intraoperative frozen section pathology, may fail to reliably distinguish between benign and malignant FNs, leading to unnecessary or inadequate surgical interventions. We aimed to develop...

Full description