Результаты поиска - Hongyan Li

Ischemic stroke (IS) is the leading cause of disability and death worldwide, and its high incidence, disability and recurrence rates impose a heavy economic burden on families and society. Recent studies have shown that oxidative stress plays a key role in the pathophysiological mechanisms of ischem...

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Objective: To explore the protective mechanism of mulberry leaf flavonoid extract (MFE) on a cellular model of diabetic encephalopathy (DE) by the combined use of network pharmacology and molecular biology. Methods: DE model was induced by subjecting PC12 cells to chronic high-glucose stimulation. C...

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ObjectiveThis study aims to reveal the suicide risk factors in specific situations of medical malpractice.MethodsWe conducted a systematic analysis using the medical malpractice case data from the judgment search system on China Judgments Online, covering the years 2012 to 2022. The χ2 test was appl...

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Abstract Introduction To evaluate whether treated with immunosuppressants in neuromyelitis optica spectrum disorder (NMOSD) shows an effect on the severity and outcomes of COVID‐19 Omicron variant. Methods This is a substudy of a single‐center clinical trial involving human umbilical cord mesenchyma...

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ABSTRACT Brown rice arouses great attention due to the enriched nutrients, but the unpleasant texture caused by bran layer limits consumer acceptance. To date, although individual enzyme or fermentation treatment has been developed to modify the rice bran, the feasibility of the combination method a...

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During the thermal processing of sea cucumbers, changes in the CFs structure affect their textural characteristics and can lead to certain nutritional losses. To clarify the effect of different Ca2+ concentrations on the CFs structure under thermal treatment, the two-step thermal processing method f...

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Cellular quiescence (G0) is a sleep-like cellular state that allows cells to maintain the ability to re-enter and exit the proliferative cycle. Quiescent cancer cells are considered a therapeutic challenge since they are often resistant to conventional chemoradiotherapy resulting in disease progress...

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Radiotherapy (RT) is a common treatment for head and neck cancers, but central nervous system function can be impaired by clinical radiation doses. This experimental study evaluated the protective efficacy of the anti-hyperglycaemic/anti-neoplastic agent phenformin against radiation-induced developm...

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BackgroundPATL2 deficiency is a significant cause of female infertility. Although multiple PATL2 missense variants have been reported in prior studies, a number of these variants remain classified as variants of uncertain significance (VUS).MethodsWe present a patient of primary infertility characte...

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Presently, integrating multi-omics information into a prediction model has become a ameliorate strategy for genomic selection to improve genomic prediction accuracy. Here, we set the genomic and transcriptomic data as the training population data, using BSLMM, TWAS, and eQTL mapping to prescreen fea...

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Left ventricular non-compaction (LVNC), is a hereditary cardiomyopathy with limited treatments. Our previous study linked phosphodiesterase 4D interacting protein (PDE4DIP) to LVNC development. To explore the functional role of PDE4DIP activation in regulating cell polarity, skeleton, and energy met...

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