Sökresultat - Hongsheng Tan

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  1. 1
    SENP1-Sirt3 axis regulates type II alveolar epithelial cell activity to confer resistance against oxidative damage in lung tissue

    SENP1-Sirt3 axis regulates type II alveolar epithelial cell activity to confer resistance against oxidative damage in lung tissue av Mingming Zhang, Xin Lin, Jianli He, Yong Zuo, Qiuju Fan, Innocent Agida, Hongsheng Tan, Caiying Zhu, Jinke Cheng, Tianshi Wang

    Publicerad 2025-09-01

    Oxidative damage exacerbates pulmonary fibrosis by impairing alveolar type II epithelial (AT2) cell function. This study demonstrates that the SUMO-specific protease 1 (SENP1)-Sirtuin 3 (Sirt3) axis, critical for mitochondrial redox regulation, is suppressed in AT2 cells during lung injury. In bleom...

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  2. 2
    Nanoparticle delivery of VEGF-B mRNA promotes T cell infiltration within tumor and triggers robust antitumor immunity

    Nanoparticle delivery of VEGF-B mRNA promotes T cell infiltration within tumor and triggers robust antitumor immunity av Geqiang Zhang, Jun Tu, Yu Zhang, Jianli He, Guoyuan Peng, Qiuju Fan, Yirong Zhang, Mingming Zhang, Hongsheng Tan, Yingjie Xu, Jinke Cheng

    Publicerad 2025-09-01

    The advancement of mRNA-based cancer immunotherapies has gained significant momentum, particularly after the success of mRNA vaccines during the COVID-19 pandemic and the recognition of mRNA vaccine development with the 2023 Nobel Prize. mRNA encoding cytokines, antibodies, and chimeric antigen rece...

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  3. 3
    Scaffold and SAR studies on c-MET inhibitors using machine learning approaches

    Scaffold and SAR studies on c-MET inhibitors using machine learning approaches av Jing Zhang, Mingming Zhang, Weiran Huang, Changjie Liang, Wei Xu, Jinghua Zhang, Jun Tu, Innocent Okohi Agida, Jinke Cheng, Dong-Qing Wei, Buyong Ma, Yanjing Wang, Hongsheng Tan

    Publicerad 2025-06-01

    Numerous c-mesenchymal-epithelial transition (c-MET) inhibitors have been reported as potential anticancer agents. However, most fail to enter clinical trials owing to poor efficacy or drug resistance. To date, the scaffold-based chemical space of small-molecule c-MET inhibitors has not been analyze...

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