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    STS2 deficiency revives CD8+T cells from exhaustion and augments checkpoint blockade efficacy in cancer immunotherapy

    STS2 deficiency revives CD8+T cells from exhaustion and augments checkpoint blockade efficacy in cancer immunotherapy by Chunxiao Li, Fei Ma, Ying Zhang, Ting Wang, Hongnan Mo, Ning Zhong, Dongkui Xu, Fangzhou Sun, Yantong Zhou, Jianbin Guo, Zhenguo Zhao, Xiaoqi Yang, Haili Qian

    Published 2025-06-01

    Background T-cell exhaustion is a major barrier to effective antitumor immunity and limits the efficacy of cancer immunotherapies. This study investigates the role of suppressor of T-cell signaling 2 (STS2, also known as UBASH3A) in regulating CD8+ T-cell exhaustion within the tumor microenvironment...

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