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    Maternal obesity impairs fetal brown adipogenesis by attenuating fetal FGF21 signaling

    Maternal obesity impairs fetal brown adipogenesis by attenuating fetal FGF21 signaling by Lun Hua, Wenxue Shen, Dengfeng Gao, Yi Yang, Xiaohan Yang, Haoqi Zhang, Siyuan Liu, Luting Liu, Yaxue Cao, Xuemei Jiang, Xingfa Han, Chao Jin, Bin Feng, Lianqiang Che, Shengyu Xu, Yan Lin, Jian Li, Zhengfeng Fang, Ting Luo, Mingzhou Li, De Wu, Yong Zhuo

    Published 2025-07-01

    Summary: In mammals, maternal obesity typically impairs brown adipose tissue (BAT) formation in fetuses, increasing their risk of metabolic disorders in adulthood. However, the mechanisms behind this phenomenon are not well understood. Our single-nucleus transcriptomic analysis revealed dynamic chan...

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