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    TREM-1 as a potential gatekeeper of neuroinflammatory responses: therapeutic validation and mechanistic insights in experimental traumatic brain injury

    TREM-1 as a potential gatekeeper of neuroinflammatory responses: therapeutic validation and mechanistic insights in experimental traumatic brain injury by Yunsheng Zhang, Yunsheng Zhang, Yunsheng Zhang, Yulian Zhang, Hanhan Dang, Hanhan Dang, Chuanpeng Zhang, Chuanpeng Zhang, Kun He, Kun He, Xu Yang, Xu Yang, Zixi Wang, Zixi Wang, Li Zhang, Li Zhang, Li Zhang, Yanbing Yu, Yanbing Yu, Yanbing Yu

    Published 2025-07-01

    BackgroundTraumatic brain injury (TBI) triggers a cascade of neuroinflammatory responses mediated by microglial activation, which significantly contributes to secondary brain damage. While triggering receptor expressed on myeloid cells-1 (TREM-1) is a key inflammatory amplifier, its mechanistic role...

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