Search Results - Haiyang Yu
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An iteration-free approach for determining the average reservoir pressure and original gas in place by production data analysis: Methodology and field cases
Published 2025-06-01Get full textCurrent gas well decline analysis under boundary-dominated flow (BDF) is largely based on the Arps' empirical hyperbolic decline model and the analytical type curve tools associated with pseudo-functions. Due to the nonlinear flow behavior of natural gas, these analysis methods generally requir...
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Targeted delivery and controlled release of polymeric nanomedicines for tumor therapy
Published 2025-07-01Get full textDrug therapy, including chemotherapy and immunotherapy, remains a cornerstone of cancer treatment; however, significant toxic side effects are often unavoidable, inhibiting tumor growth while causing damage to multiple organ systems. Polymeric nanomedicines have shown substantial promise in addressi...
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Enhancing head and neck cancer detection accuracy in digitized whole-slide histology with the HNSC-classifier: a deep learning approach
Published 2025-08-01Get full textHead and neck squamous cell carcinoma (HNSCC) represents the sixth most common cancer worldwide, with pathologists routinely analyzing histological slides to diagnose cancer by evaluating cellular heterogeneity, a process that remains time-consuming and labor-intensive. Although no previous studies...
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Bisphenol A in utero induced glutamate and D-serine metabolic dysregulation in the hippocampus of rats and primary cultured astrocytes
Published 2025-09-01Get full textBisphenol A (BPA) is a widely used synthetic compound that could cause neurobehavioral abnormalities in mammals. Previous studies have suggested that NMDAR may be a potential target of BPA-induced neurotoxicity. However, the impact of exposure to BPA on glutamate (Glu) and D-serine (D-ser) metabolis...
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Study of the Function and Expression of the AhRUVBL2 Promoter in Arabidopsis
Published 2025-06-01Get full textBackground: Cultivated peanut (Arachis hypogaea L.) is a major oil and economic crop. Pod size is one of the important agronomic traits of peanut variety, with a direct impact on peanut yield. Methods:...
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Transcriptomic Profiling of Thermotolerant <i>Sarcomyxa edulis</i> PQ650759 Reveals the Key Genes and Pathways During Fruiting Body Formation
Published 2025-06-01Get full text<i>Sarcomyxa edulis</i> is a characteristic low-temperature, edible mushroom in Northeast China. It has a delicious taste and rich nutritional and medicinal value. <i>S. edulis</i> can undergo explosive fruiting, neat fruiting, and unified harvesting, making it suitable for f...
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Mcl-1 suppresses abasic site repair following bile acid–induced hepatic cellular DNA damage
Published 2017-07-01Get full textIn cholestasis, increases in bile acid levels result in the generation of reactive oxygen species and the induction of DNA damage and mutation. It is believed that bile acid accumulation is associated with liver tumorigenesis. However, the mechanism that underpins this phenomenon remains to be eluci...
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Characterization and functional analysis of BRCA1 and BRCA2 variants in a cohort of 100 unselected patients undergoing germline screening
Published 2025-09-01Get full textGermline loss-of-function mutations in BRCA1 and BRCA2 (BRCA) genes are well-established as causative factors for hereditary breast and ovarian cancer (HBOC), conferring an approximately tenfold increased lifetime risk. The identification of BRCA mutations is essential for risk assessment and manage...
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