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    Moracin M derivative targeting PDE4 for the treatment of psoriasis

    Moracin M derivative targeting PDE4 for the treatment of psoriasis by Liru Chen, Deyan Wu, Sen Wang, Lingyu Wu, Youyou Chen, Baoli Li, Haibin Luo, Jian Li, Wenwen Liu

    Published 2025-02-01

    Phosphodiesterase-4 (PDE4), a member of the phosphodiesterase superfamily, has highly important roles in cyclic nucleotide signaling pathways and a variety of skin disorders. Blocking PDE4 activity with PDE4 inhibitors increases intracellular cAMP levels and effectively relieves the skin inflammator...

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