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    Engineered small extracellular vesicles for targeted delivery of perlecan to stabilise the blood–spinal cord barrier after spinal cord injury

    Engineered small extracellular vesicles for targeted delivery of perlecan to stabilise the blood–spinal cord barrier after spinal cord injury by Wei Peng, Wentao Zhang, Wei Cui, Wenjin Chen, Yin Zhuang, Rupeng Chu, Jinghua Tan, Jingbo Xue, Yiguo Yan, Guoyong Yin, Shujun Zhang, Yong Xie

    Published 2025-06-01

    Abstract Background Destruction of the blood–spinal cord barrier (BSCB) following spinal cord injury (SCI) can result in various harmful cytokines, neutrophils, and macrophages infiltrating into the injured site, causing secondary damage. Growing evidence shows that M2 macrophages and their small ex...

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