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    High-throughput modular click chemistry synthesis of catechol derivatives as covalent inhibitors of SARS-CoV-2 3CL pro

    High-throughput modular click chemistry synthesis of catechol derivatives as covalent inhibitors of SARS-CoV-2 3CL pro by Feng Wang, Tiancheng Ma, Donglan Liu, Yixin Cen, Shidong Deng, Lu Zhang, Guoqiang Lin, Dingding Gao, Jincun Zhao, Jiajia Dong, Ping Tian

    Published 2024-08-01

    The 3C-like protease (3CL pro ) is a crucial target in anti-Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) drug design. Herein, we performed high-throughput synthesis of catechol derivatives from the bioactive catechol-terminal alkyne scaffold A4 , by using modular click chemistry. Su...

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