Αποτελέσματα αναζήτησης - Gengfu Xiao
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Functional Characterization of a Lassa Virus Fusion Inhibitor Adaptive Mutant
Έκδοση 2025-01-01Λήψη πλήρους κειμένουLassa virus (LASV) glycoprotein complex (GPC) contains retained stable-signal peptide (SSP), glycoprotein 1 (GP1), and glycoprotein 2 (GP2). Through serial passaging of LASV with inhibitors, adaptive mutants were obtained, most of which had mutations in the transmembrane (TM) domain of GP2. Characte...
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Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease
Έκδοση 2025-07-01Λήψη πλήρους κειμένουAbstract Monkeypox virus (MPXV), an orthopoxvirus that has long been endemic in Africa, has posed a significant global health threat since 2022. The I7L protease, a highly conserved cysteine proteinase essential for orthopoxvirus replication, represents a promising target for broad‐spectrum antivira...
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