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    The deficiency of chymase mast cell protease 4 exacerbates dextran sulfate sodium salt-induced colitis in mice and is associated with altered microbiota and metabolome profiles

    The deficiency of chymase mast cell protease 4 exacerbates dextran sulfate sodium salt-induced colitis in mice and is associated with altered microbiota and metabolome profiles by Zhiqiang Li, Zhiqiang Li, Zhiqiang Li, Xiaoyuan Kuang, Dashuang Mo, Magnus Åbrink, Ge Shan, Jin-ping Li, Can Yang, Yuexi Wang, Tao Shen, Weiwei Yu

    Published 2025-07-01

    IntroductionUlcerative colitis (UC) is a chronic gastrointestinal disease characterized by symptoms of abdominal pain and diarrhea. Chymase is a serine protease released by the mast cells and is highly expressed in patients with UC. However, its role in disease pathogenesis remains poorly understoo...

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